1 型与 2 型糖尿病对带状疱疹及带状疱疹后神经痛发病的影响：一项基于人群的队列研究。
Impact of Type 1 Versus Type 2 Diabetes on Developing Herpes Zoster and Post-herpetic Neuralgia: A Population-based Cohort Study.
机构信息
School of Management, National Taiwan University of Science and Technology, Taipei, Taiwan; Department of Dermatology, Taipei City Hospital, Renai Branch, Taipei, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Science, Taipei, Taiwan; Department of Cosmetic Applications and Management, Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; Department of Health and Welfare, University of Taipei, Taipei, Taiwan,.
Department of Industrial Management, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
出版信息
Acta Derm Venereol. 2023 Oct 3;103:adv9400. doi: 10.2340/actadv.v103.9400.
Type 2 diabetes is associated with an increased risk of herpes zoster and postherpetic neuralgia. However, the association of type 1 diabetes with herpes zoster or postherpetic neuralgia remains unclear. This retrospective cohort study using Taiwan's Health Insurance Research Database included 199,566 patients with type 1 diabetes and 1,458,331 with type 2 diabetes, identified during the period 2000 to 2012. Patients with type 1 diabetes had a significantly higher risk of developing herpes zoster than those with type 2 diabetes (p < 0.001). Across all age groups, the impact of diabetes on herpes zoster was greater in type 1 than in type 2 diabetes. Patients with both type 1 and type 2 diabetes had a 1.45-fold higher risk of post-herpetic neuralgia than those without diabetes (hazard ratio 1.45, 95% confidence interval 1.28-1.65; hazard ratio 1.45, 95% confidence interval 1.37-1.52, respectively), and there was no difference between the 2 types of diabetes (hazard ratio 1.06; 95% confidence interval 0.93-1.21). The results recommend consideration of herpes zoster vaccination at an earlier age in patients with type 1 diabetes.
2 型糖尿病与带状疱疹和带状疱疹后神经痛的风险增加有关。然而，1 型糖尿病与带状疱疹或带状疱疹后神经痛的关联仍不清楚。本研究使用台湾健康保险研究数据库进行了一项回顾性队列研究，纳入了 199566 例 1 型糖尿病患者和 1458331 例 2 型糖尿病患者，这些患者均在 2000 年至 2012 年期间确诊。与 2 型糖尿病患者相比，1 型糖尿病患者发生带状疱疹的风险显著更高（p<0.001）。在所有年龄组中，糖尿病对带状疱疹的影响在 1 型糖尿病中大于 2 型糖尿病。与无糖尿病患者相比，1 型和 2 型糖尿病患者发生带状疱疹后神经痛的风险分别高出 1.45 倍（风险比 1.45，95%置信区间 1.28-1.65；风险比 1.45，95%置信区间 1.37-1.52），两种类型的糖尿病之间没有差异（风险比 1.06；95%置信区间 0.93-1.21）。这些结果建议在 1 型糖尿病患者中更早考虑带状疱疹疫苗接种。
Zotero 插件