Liu Yong, Liu Hui, Bian Queqiao, Zhang Shuhuan, Guan Yanmin
Department of Dermatology & STD, The Third Central Hospital of Tianjin; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases; Artificial Cell Engineering Technology Research Center; Tianjin Institute of Hepatobiliary Disease, Tianjin, People's Republic of China.
Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Aug 26;17:1905-1915. doi: 10.2147/CCID.S471823. eCollection 2024.
Herpes zoster (HZ) and postherpetic neuralgia (PHN) significantly affect patients' quality of life (QoL). Cultural differences may lead to different patient-reported outcomes across countries. The current study aims to evaluate the detrimental impact of HZ and PHN on QoL in China.
This prospective study was conducted from January 2020 to April 2023. We used the Zoster Brief Pain Inventory (ZBPI) and 5-level EuroQol-5 Dimension (EQ-5D-5L) questionnaire to assess the QoL of HZ and PHN patients. Patients were required to complete the questionnaires at 15, 30, 60, and 90 days after the onset of the HZ rash. Additional questionnaires were administered at 120, 150, and 180 days for those who developed PHN within three months of the rash's onset.
A cohort of 633 patients with a median age of 63 years were included in the study. The mean delay from the appearance of the initial HZ rash to the first medical consultation was 5.1 ± 2.8 days. Approximately 30% of the HZ patients (189/633) went on to develop PHN. For patients with HZ who did not progress to PHN, the ZBPI worst pain score and impaired QoL had nearly resolved by day 90 post-rash onset. Conversely, there was no significant improvement in the ZBPI worst pain score and QoL for those with PHN, even by day 180 post-rash onset.
Both HZ and PHN significantly impaired patients' QoL. However, the impairment caused by PHN was more severe in both intensity and duration.
带状疱疹（HZ）和带状疱疹后神经痛（PHN）严重影响患者的生活质量（QoL）。文化差异可能导致不同国家患者报告的结果有所不同。本研究旨在评估HZ和PHN对中国患者生活质量的有害影响。
本前瞻性研究于2020年1月至2023年4月进行。我们使用带状疱疹简明疼痛量表（ZBPI）和5级欧洲五维度健康量表（EQ-5D-5L）问卷来评估HZ和PHN患者的生活质量。患者需在HZ皮疹发作后的第15、30、60和90天完成问卷。对于在皮疹发作后三个月内发生PHN的患者，在第120、150和180天进行额外问卷调查。
本研究纳入了633例患者，中位年龄为63岁。从最初出现HZ皮疹到首次就诊的平均延迟时间为5.1±2.8天。约30%的HZ患者（189/633）继而发展为PHN。对于未进展为PHN的HZ患者，ZBPI最严重疼痛评分和受损的生活质量在皮疹发作后90天几乎已恢复。相反，对于患有PHN的患者，即使在皮疹发作后180天，ZBPI最严重疼痛评分和生活质量也没有显著改善。
HZ和PHN均显著损害患者的生活质量。然而，PHN造成的损害在强度和持续时间上更为严重。
