Department of Cardiology, Cardiovascular Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Department of Neurology, Peking University International Hospital, Beijing 102206, China.
Aging (Albany NY). 2023 Oct 2;15(19):10117-10132. doi: 10.18632/aging.205061.
Placental growth factor (PlGF), an important polypeptide hormone, plays an important regulatory role in various physiological processes. Observational studies have shown that PlGF is associated with the risk of coronary heart disease (CHD). However, the causal association between PlGF and CHD is unclear at present. This study aimed to investigate the causal association between genetically predicted PlGF levels and CHD.
Single nucleotide polymorphisms (SNPs) associated with PlGF were selected as instrumental variables (IVs) to evaluate the causal association between genetically predicted circulating PlGF levels and CHD risk by two-sample Mendelian randomization (MR).
Inverse variance weighted (IVW) analysis showed that there was a suggestive causal association between genetically predicted PlGF level and the risk of CHD (OR = 0.79, 95% CI: 0.66-0.95, = 0.011) overall. In addition, PlGF levels had a significant negative causal association with the risk of myocardial infarction (OR = 0.83, 95% CI: 0.72-0.95, = 0.007). A negative correlation trend was found between PlGF level and the risk of angina pectoris (OR = 0.89, 95% CI: 0.79-1.01, = 0.067). In addition, PlGF levels had a significant negative association with the risk of unstable angina pectoris (OR = 0.78, 95% CI: 0.64-0.94, = 0.008). PlGF levels were negatively correlated with CHD events with suggestive significance (OR = 0.89, 95% CI: 0.80-0.99, = 0.046).
Genetically predicted circulating PlGF levels are causally associated with the risk of CHD, especially acute coronary syndrome, and PlGF is a potential therapeutic target for CHD.
胎盘生长因子（PlGF）是一种重要的多肽激素，在各种生理过程中发挥着重要的调节作用。观察性研究表明，PlGF 与冠心病（CHD）的风险相关。然而，目前尚不清楚 PlGF 与 CHD 之间是否存在因果关系。本研究旨在探讨遗传预测的 PlGF 水平与 CHD 之间的因果关系。
选择与 PlGF 相关的单核苷酸多态性（SNP）作为工具变量（IVs），通过两样本 Mendelian 随机化（MR）评估遗传预测的循环 PlGF 水平与 CHD 风险之间的因果关系。
逆方差加权（IVW）分析表明，遗传预测的 PlGF 水平与 CHD 风险之间存在提示性因果关系（OR=0.79，95%CI：0.66-0.95， = 0.011）。此外，PlGF 水平与心肌梗死（OR=0.83，95%CI：0.72-0.95， = 0.007）的风险之间存在显著的负向因果关系。PlGF 水平与稳定性心绞痛（OR=0.89，95%CI：0.79-1.01， = 0.067）的风险之间呈负相关趋势。此外，PlGF 水平与不稳定型心绞痛（OR=0.78，95%CI：0.64-0.94， = 0.008）的风险呈显著负相关。PlGF 水平与 CHD 事件呈负相关（OR=0.89，95%CI：0.80-0.99， = 0.046），具有提示意义。
遗传预测的循环 PlGF 水平与 CHD 的风险呈因果关系，尤其是急性冠状动脉综合征，PlGF 可能是 CHD 的潜在治疗靶点。
