Cardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, Changchun, Jilin Province, China.
Cardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, Changchun, Jilin Province, China.
Nutr Metab Cardiovasc Dis. 2023 Dec;33(12):2406-2412. doi: 10.1016/j.numecd.2023.08.003. Epub 2023 Aug 14.
Observational studies have demonstrated that serum branched-chain amino acids (BCAAs) are associated with the risk of various cardiovascular diseases (CVDs) and their risk factors. However, the causal effect is unclear. The aim of this study was to investigate the effect of genetically determined BCAA levels on CVDs and their risk factors using Mendelian randomization (MR).
We performed univariable and multivariable MR analyses using summary-level data from multiple GWASs and the FinnGen consortium to investigate the association between BCAA levels and the risk of CVDs (myocardial infarction, ischemic stroke, and intracerebral hemorrhage) and their risk factors (atrial fibrillation, hypertension, heart failure, and valvular heart disease). We used the random-effects IVW approach as the primary statistical method and incorporated MR estimates from different data sources using the fixed-effects model. We found genetically determined total and individual BCAA levels and a high risk of hypertension. However, there is no evidence of a causal relationship between BCAA levels and 3 cardiovascular diseases and other their risk factors. The odds of hypertension increased per 1-SD increase in BCAA levels (OR = 1.02 95% CI: 1.01, 1.04; P = 0.005), valine (OR = 1.02 95% CI: 1.01, 1.03; P<0.0001), leucine (OR = 1.02 95% CI: 1.01, 1.04; P＜0.01), and isoleucine (OR = 1.02 95% CI: 1.01, 1.03; P < 0.0001). This result was also significant in the multivariable MR.
This MR study suggests that total and individual BCAA levels could be associated with a high risk of hypertension.
观察性研究表明，血清支链氨基酸（BCAA）与各种心血管疾病（CVD）及其危险因素的风险相关。然而，因果关系尚不清楚。本研究旨在使用孟德尔随机化（MR）研究遗传决定的 BCAA 水平对 CVD 及其危险因素的影响。
我们使用来自多个 GWAS 和芬兰人群研究联合会（FinnGen consortium）的汇总水平数据进行单变量和多变量 MR 分析，以研究 BCAA 水平与 CVD（心肌梗死、缺血性卒中和脑出血）及其危险因素（心房颤动、高血压、心力衰竭和瓣膜性心脏病）风险之间的关联。我们使用随机效应 IVW 方法作为主要统计方法，并使用固定效应模型合并来自不同数据源的 MR 估计值。我们发现遗传决定的总 BCAA 和个体 BCAA 水平与高血压风险增加有关。然而，没有证据表明 BCAA 水平与 3 种心血管疾病和其他危险因素之间存在因果关系。BCAA 水平每增加 1-SD，高血压的风险增加（OR=1.02 95%CI：1.01，1.04；P=0.005），缬氨酸（OR=1.02 95%CI：1.01，1.03；P<0.0001），亮氨酸（OR=1.02 95%CI：1.01，1.04；P<0.01）和异亮氨酸（OR=1.02 95%CI：1.01，1.03；P<0.0001）。多变量 MR 也得到了同样显著的结果。
本 MR 研究表明，总 BCAA 和个体 BCAA 水平可能与高血压风险增加有关。
