Isabel Lucío María, Giacalone Francesco, La Parola Valeria, Gámez-Valenzuela Sergio, Muñoz-Alba Fernando, Ruiz Delgado M Carmen, Herrero M Antonia, Vázquez Ester
Departamento de Química Inorgánica, Orgánica y Bioquímica, Facultad de Ciencias y Tecnologías Químicas-IRICA, Universidad de Castilla-La Mancha, 13071, Ciudad Real, Spain.
Instituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, 13071, Ciudad Real, Spain.
Chemistry. 2023 Dec 22;29(72):e202302476. doi: 10.1002/chem.202302476. Epub 2023 Nov 6.
The functionalisation of carbon nanotubes has been instrumental in broadening its application field, allowing especially its use in biological studies. Although numerous covalent and non-covalent functionalisation methods have been described, the characterisation of the final materials has always been an added challenge. Among the various techniques available, Raman spectroscopy is one of the most widely used to determine the covalent functionalisation of these species. However, Raman spectroscopy is not a quantitative technique, and no studies are reported comparing its performance when the same number of functional groups are added but using completely different reactions. In this work, we have experimentally and theoretically studied the functionalisation of carbon nanotubes using two of the most commonly used reactions: 1,3-dipolar cycloaddition of azomethylene ylides and diazonium-based radical addition. The number of groups introduced onto the tubes by these reactions has been determined by different characterisation techniques. The results of this study support the idea that data obtained by Raman spectra are only helpful for comparing functionalisations produced using the same type of reaction. However, they should be carefully analysed when comparing functionalisations produced using different reaction types.
碳纳米管的功能化对于拓宽其应用领域起到了重要作用，尤其使其能够用于生物学研究。尽管已经描述了许多共价和非共价功能化方法，但最终材料的表征始终是一个额外的挑战。在各种可用技术中，拉曼光谱是用于确定这些物质共价功能化的最广泛使用的技术之一。然而，拉曼光谱不是一种定量技术，并且没有研究报告在添加相同数量的官能团但使用完全不同的反应时比较其性能。在这项工作中，我们通过实验和理论研究了使用两种最常用反应对碳纳米管进行的功能化：氮杂亚甲基叶立德的1,3-偶极环加成反应和基于重氮盐的自由基加成反应。通过这些反应引入到碳纳米管上的官能团数量已通过不同的表征技术确定。这项研究的结果支持这样一种观点，即通过拉曼光谱获得的数据仅有助于比较使用相同类型反应产生的功能化。然而，在比较使用不同反应类型产生的功能化时，应仔细分析这些数据。
