Metagenomics as New Tool for Diagnosis of Scrub Typhus: Two Case Reports.

Scrub typhus is a vector-borne infectious disease caused by . Accurate and timely diagnosis at the early infection stage could save the patients' lives. Traditional technologies were limited to rapidly and successfully detecting due to poor specificity, especially in the condition of atypical symptoms. The technology of Metagenomic next-generation sequencing (mNGS) is amenable to finding the real pathogen because it holds potential as a diagnostic platform for unbiased pathogen identification and precision medicine. Herein, we reported two clinical case reports relative to the infection diagnosed by mNGS. We hope these two cases will improve clinical diagnosis.