Maringanti Babu Sriram, Ganipisetti Venu M, Jun Scott S, Flores Mario I
Hospital Medicine, University of New Mexico, Albuquerque, USA.
Hospital Medicine, Presbyterian Hospital, Albuquerque, USA.
Cureus. 2023 Sep 1;15(9):e44538. doi: 10.7759/cureus.44538. eCollection 2023 Sep.
Acute pancreatitis is a frequent cause of hospitalization, with the most common triggers being alcohol consumption and gallstones. Although the incidence of drug-induced pancreatitis remains low, it is steadily increasing due to the advent of newly discovered broad-spectrum antibiotics targeting multi-drug resistant organisms. Tigecycline, a broad-spectrum intravenous antibiotic derived from the tetracycline class, was approved by the FDA in 2005 for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired pneumonia. It has activity against vancomycin-resistant Enterococcus, Methicillin-resistant , multi-drug-resistant , multi-drug-resistant , and Extended Spectrum Beta-lactamase (ESBL) producing Enterobacter species. However, it was later discovered that tigecycline can cause acute pancreatitis. We present a case of a 27-year-old female patient who was admitted to the emergency department with abdominal pain and was subsequently diagnosed with tigecycline-induced pancreatitis based on the clinical resolution after withdrawal of the drug.
急性胰腺炎是住院治疗的常见病因，最常见的诱因是饮酒和胆结石。尽管药物性胰腺炎的发病率仍然较低，但由于针对多重耐药菌的新型广谱抗生素的出现，其发病率正在稳步上升。替加环素是一种源自四环素类的广谱静脉用抗生素，于2005年被美国食品药品监督管理局（FDA）批准用于治疗复杂性皮肤及皮肤结构感染、复杂性腹腔内感染和社区获得性肺炎。它对耐万古霉素肠球菌、耐甲氧西林、多重耐药、多重耐药以及产超广谱β-内酰胺酶（ESBL）的肠杆菌属具有活性。然而，后来发现替加环素可导致急性胰腺炎。我们报告一例27岁女性患者，因腹痛入住急诊科，随后根据停药后的临床缓解情况被诊断为替加环素诱导的胰腺炎。
