Jegorović Boris, Nikolić Aleksandra, Milinković Neda, Ignjatović Svetlana, Šipetić-Grujičić Sandra
University Clinical Center of Serbia, Clinic for Infectious and Tropical Diseases "Prof. Dr. Kosta Todorović", Belgrade.
University of Belgrade, Faculty of Medicine, Institute for Epidemiology, Belgrade.
J Med Biochem. 2023 Aug 25;42(3):492-504. doi: 10.5937/jomb0-42799.
The unpredictable course of Coronavirus Disease 19 (COVID-19) is making good severity assessment tools crucial. This study aimed to assess the usefulness of serum amyloid A (SAA) and other acute-phase reactants (APRs) in ambulatory care COVID-19 patients and identified relationships between these markers and disease outcomes.
From August to November 2020, patients seen in the outpatient department of the Clinic for Infectious and Tropical Diseases (Belgrade, Serbia) with confirmed COVID-19 were included. Patients were classified into mild, moderate, and severe disease groups based on World Health Organization criteria. SAA, C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), ferritin, fibrinogen, D-dimer, albumin, and transferrin were measured. The median values of all APRs were compared between COVID-19 severity groups, hospitalized and non-hospitalized patients, and survivors and non-survivors. The Receiver operator characteristic (ROC) curve analysis was used for the classification characteristics assessment of individual APRs for the severity of illness, hospitalization, and survival.
新型冠状病毒肺炎（COVID-19）病程难以预测，因此有效的病情严重程度评估工具至关重要。本研究旨在评估血清淀粉样蛋白A（SAA）及其他急性期反应物（APR）在门诊COVID-19患者中的应用价值，并确定这些标志物与疾病转归之间的关系。
纳入2020年8月至11月在塞尔维亚贝尔格莱德传染病与热带病诊所门诊确诊为COVID-19的患者。根据世界卫生组织标准将患者分为轻症、中症和重症疾病组。检测SAA、C反应蛋白（CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）、铁蛋白、纤维蛋白原、D-二聚体、白蛋白和转铁蛋白。比较COVID-19不同严重程度组、住院和非住院患者以及幸存者和非幸存者中所有APR的中位数。采用受试者工作特征（ROC）曲线分析评估各APR对疾病严重程度、住院和生存情况的分类特征。
