Liang Junyi, Liu Bin, Dong Xiaohong, Wang Yueyang, Cai Wenhui, Zhang Ning, Zhang Hong
Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Heilongjiang Jiamusi Central Hospital, Jiamusi, Heilongjiang, China.
Front Neurosci. 2023 Sep 18;17:1242254. doi: 10.3389/fnins.2023.1242254. eCollection 2023.
Alzheimer's disease (AD) emerges as a perturbing neurodegenerative malady, with a profound comprehension of its underlying pathogenic mechanisms continuing to evade our intellectual grasp. Within the intricate tapestry of human health and affliction, the enteric microbial consortium, ensconced within the milieu of the human gastrointestinal tract, assumes a role of cardinal significance. Recent epochs have borne witness to investigations that posit marked divergences in the composition of the gut microbiota between individuals grappling with AD and those favored by robust health. The composite vicissitudes in the configuration of the enteric microbial assembly are posited to choreograph a participatory role in the inception and progression of AD, facilitated by the intricate conduit acknowledged as the gut-brain axis. Notwithstanding, the precise nature of this interlaced relationship remains enshrouded within the recesses of obscurity, poised for an exhaustive revelation. This review embarks upon the endeavor to focalize meticulously upon the mechanistic sway exerted by the enteric microbiota upon AD, plunging profoundly into the execution of interventions that govern the milieu of enteric microorganisms. In doing so, it bestows relevance upon the therapeutic stratagems that form the bedrock of AD's management, all whilst casting a prospective gaze into the horizon of medical advancements.
阿尔茨海默病（AD）是一种令人困扰的神经退行性疾病，我们仍未完全理解其潜在的致病机制。在人类健康与疾病的复杂图景中，存在于人类胃肠道环境中的肠道微生物群落起着至关重要的作用。近年来的研究表明，患有AD的个体与健康个体的肠道微生物群组成存在显著差异。肠道微生物组合结构的复杂变化被认为通过被称为肠脑轴的复杂途径，在AD的发生和发展中发挥参与作用。然而，这种交织关系的确切性质仍隐藏在未知之中，有待全面揭示。本综述致力于精心聚焦肠道微生物群对AD的作用机制，深入探讨调控肠道微生物环境的干预措施的实施情况。在此过程中，它强调了构成AD治疗基础的治疗策略的相关性，同时展望了医学进步的前景。
