Agadzhanian M G, Smirnova I N, Sidorova E V
Biull Eksp Biol Med. 1986 Nov;102(11):589-92.
Immunization of irradiated and syngeneic splenocyte-treated CBA mice with bovine red blood cells stimulated the formation of both antigen-producing cells (APC) and antigen-dependent nonspecific immunoglobulin-producing cells (NIGPC). The injection of G0-cell-enriched, instead of normal, splenocytes (together with bovine RBC) to irradiated mice reduced by half the production of antigen-dependent NIGPC. Thus, it is evident, that some of them are formed from preexisting blast cells (G1). An additional removal of antigen-binding cells (ABC) from G0 lymphocyte population produced a still greater reduction in NIGPC formation (the increment was 92.3% lower than in the control). It is concluded that antigen-dependent NIGPC are formed both due to specific antigen-stimulation of G0 cells aid to nonspecific stimulation of blast cells with factors produced by antigen-stimulated T-cells.
用牛红细胞对经照射并经同基因脾细胞处理的CBA小鼠进行免疫，刺激了抗原产生细胞（APC）和抗原依赖性非特异性免疫球蛋白产生细胞（NIGPC）的形成。给经照射的小鼠注射富含G0细胞而非正常脾细胞（与牛红细胞一起），使抗原依赖性NIGPC的产生减少了一半。因此，很明显，其中一些是由预先存在的母细胞（G1）形成的。从G0淋巴细胞群体中额外去除抗原结合细胞（ABC），导致NIGPC形成的减少幅度更大（增加量比对照组低92.3%）。得出的结论是，抗原依赖性NIGPC的形成既是由于G0细胞的特异性抗原刺激，也是由于抗原刺激的T细胞产生的因子对母细胞的非特异性刺激。
