[小鼠存活率与S特异性药物——羟基脲给药间隔之间关系的共振性质]
[Resonance nature of the relation of mouse survival to the interval between administrations of the S-specific agent--hydroxyurea].
作者信息
Dibrov B F, Ataullakhanov A N, Gel'fand E V, Zhabotinskiĭ A M, Neĭfakh Iu A
出版信息
Biull Eksp Biol Med. 1986 Nov;102(11):594-6.
PMID:3779090
Abstract
The dependence of murine survival on the intervals between periodic hydroxyurea (HU) injections was studied. The single dose of HU comprised 250 mg per kg. Intervals between injections varied from 5 to 19 hours while their number changed from 6 to 9 in different experiments. A resonant increase in the survival was observed under HU administered every 8-9 or 16 1/2 hours.
摘要
研究了小鼠存活率对周期性注射羟基脲（HU）间隔时间的依赖性。HU的单次剂量为每千克250毫克。不同实验中，注射间隔时间从5小时到19小时不等，注射次数从6次到9次不等。每8 - 9小时或16.5小时注射一次HU时，观察到存活率有显著提高。
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