[Relation of the survival of mouse hematopoietic stem cells to the interval between periodic injections of hydroxyurea].

The dependence was studied between the survival of proliferating hemopoietic stem cells (CFUs) on the interval between regular multiple injections of hydroxyurea (HU). Before HU injection mice were irradiated in a dose of 200 rad to trigger the proliferation of CFUs. The dependence obtained is resonance in character, with a maximum being attained during injections made with a 12-hour interval. Comparison with the mathematical model indicates that interval corresponding with the maximal survival should correlate with the mean time of the generation of proliferating CFUs.