Georgiev V P, Petkova B P
Acta Physiol Pharmacol Bulg. 1978;4(4):36-42.
A comparative study is made of the effect of centrophenoxine (CP) on the picrotoxin convulsive-seizure threshold (PCST) in non-irradiated and irradiated 3 and 7 days previously male mice. It is found that the CP appliked intracerebroventricularly in doses of 200 and 400 micrograms/mouse (weight 18-22 g), increases PCST. In non-irradiated mice the PCST-increasing effect of CP occurs rapidly (5 min) and it is brief (it can be observed until the 15th min). When the irradiation is performed three days previously, the PCST-increasing effect of CP is prolonged (it is observed until the 6th hour after its application). When the irradiation is performed seven days previously the characteristic features of the PCST-increasing effect of CP are similar to those in the early stage (3 days), the only difference being that the duration of the effect is prolonged to 120 min. Generally, these specificities of the CP effect are valid for all three phases of the convulsive seizure (general excitation, clonic convulsive seizure and tonic convulsive seizure.
对盐酸甲氯芬酯（CP）对未受辐照以及3天和7天前受过辐照的雄性小鼠的印防己毒素惊厥阈值（PCST）的影响进行了一项比较研究。结果发现，以200和400微克/小鼠（体重18 - 22克）的剂量脑室内注射CP，会提高PCST。在未受辐照的小鼠中，CP提高PCST的作用出现迅速（5分钟）且持续时间短暂（直至第15分钟仍可观察到）。若3天前进行过辐照，CP提高PCST的作用会延长（直至给药后第6小时仍可观察到）。若7天前进行过辐照，CP提高PCST作用的特征与早期阶段（3天）相似，唯一的区别在于作用持续时间延长至120分钟。总体而言，CP作用的这些特异性在惊厥发作的所有三个阶段（全身兴奋、阵挛性惊厥发作和强直性惊厥发作）均有效。
