Georgiev V, Chavdarov D, Petkov V, Kirilov B
Acta Physiol Pharmacol Bulg. 1979;5(3):59-66.
The effects of centrophenoxine on the release of acetylcholine and on the changes in the bioelectrical activity are determined in experiments on non-anaesthesized cats subjected to perfusion of the anterior horn of the lateral cerebral ventricle and simultaneous recording of the bioelectrical activity of cortical and subcortical structures. Centrophenoxine is tested in doses of 25, 50 and 100 mg/kg intravenously. Most characteristic changes are found to occur after the dose of 50 mg/kg, when centrophenoxine markedly increases the amount of the released acetylcholine and changes the bioelectrical activity (synchronous changes in the cortex and hypothalamus). The parallelism between the increase release of acetylcholine and the bioelectrical changes continued until the time of the peak effect of centrophenoxine (45 min), followed by dissociation between them (the level of the released acetylcholine gradually approached the initial level, while the changed bioelectrical activity persisted for a longer time.
在对未麻醉猫进行的实验中，通过向侧脑室前角灌注并同时记录皮质和皮质下结构的生物电活动，来确定盐酸甲氯芬酯对乙酰胆碱释放以及生物电活动变化的影响。静脉注射剂量为25、50和100mg/kg的盐酸甲氯芬酯进行测试。发现大多数特征性变化发生在50mg/kg剂量之后，此时盐酸甲氯芬酯显著增加乙酰胆碱的释放量并改变生物电活动（皮质和下丘脑的同步变化）。乙酰胆碱释放增加与生物电变化之间的平行关系一直持续到盐酸甲氯芬酯的峰值效应出现时（45分钟），随后两者出现分离（释放的乙酰胆碱水平逐渐接近初始水平，而改变的生物电活动持续更长时间）。
