Namer M, Boublil J L, Kather R, Cavaglione G
Bull Cancer. 1986;73(1):47-55.
Beside orchiectomy and estrogens, other endocrine manipulations are proposed for metastatic prostatic cancer patients. Antiandrogens, Cyproterone acetate and Flutamide, are often less efficient but less toxic than DES. Progestational agents medroxyprogesterone acetate, megoestrol acetate, chlormadinone acetate have also a limited activity. Inversely, tamoxifen is very little active. Preliminary results of ketoconazole need more controls. The present aims are to obtain, particularly by hormonal association, a more efficient and less toxic treatment, when DES can be given initially or becomes inefficient.
除睾丸切除术和雌激素外，还为转移性前列腺癌患者提出了其他内分泌治疗方法。抗雄激素药物醋酸环丙孕酮和氟他胺的疗效通常较低，但毒性比己烯雌酚小。孕激素类药物醋酸甲羟孕酮、醋酸甲地孕酮、醋酸氯地孕酮的活性也有限。相反，他莫昔芬的活性很小。酮康唑的初步结果需要更多对照验证。目前的目标是，特别是通过激素联合使用，在最初可以使用己烯雌酚或其疗效不佳时，获得一种更有效且毒性更小的治疗方法。
