Acute responses and chronic adaptations to exercise in humans: a look from the autonomic nervous system window.

The objective of this review was to give an overview on the current knowledge on the neural mechanisms of cardiovascular regulation during acute exercise and the autonomic adaptations brought about by chronic exercise, that is, exercise training. Evidence derived mainly from human studies, which supports the contribution of the different control mechanisms, namely the centralcommand, the reflex drive from active muscles and the arterial baroreflex, with the attendant modifications in autonomic nervous system activity, in determining the acute cardiovascular responses to exercise are discussed, along with some controversial issues and evolving concepts in exercise physiology. In particular, data that show how the various neural mechanisms involved in cardiovascular regulation during exercise are differently modulated by factors related to the muscular activity being performed, such as the type and intensity of exercise and the size of the active muscle masses are presented, stressing the plasticity of the neural network. Thereafter, the clinical implications pertaining neural cardiovascular adaptations to exercise training are presented and discussed, in the context of cardiac diseases. In particular, I will summarize a series of investigations performed in our laboratory that utilized a new training methodology and different exercise formats to quantify the training load in cardiac patients. The way by which individualized exercise training doses affects the autonomic nervous system and the cardiorespiratory adaptations is highlighted.