Milzarek Tobias M, Ramirez Nieves P, Liu Xing-Yu, Waser Jerome
Laboratory of Catalysis and Organic Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Chem Commun (Camb). 2023 Oct 19;59(84):12637-12640. doi: 10.1039/d3cc04525k.
Bis(trifluoromethylated)benziodoxoles (Bx) are broadly used cyclic hypervalent iodine reagents due to their stability and unique chemical properties. However, current methods to access them require several steps and long reaction times, making their synthesis tedious. Herein, a direct one-pot synthesis of bis(trifluoromethylated) Bx reagents from iodine(I) precursors is reported, enabling the synthesis of functionalized reagents.
双（三氟甲基化）苯并碘杂环戊二烯（Bx）因其稳定性和独特的化学性质而被广泛用作环状高价碘试剂。然而，目前制备它们的方法需要多个步骤和较长的反应时间，使得其合成过程繁琐。在此，报道了一种由碘（I）前体直接一锅法合成双（三氟甲基化）Bx试剂的方法，从而能够合成功能化试剂。
