Angel M F, Narayanan K, Swartz W M, Ramasastry S S, Kuhns D B, Basford R E, Futrell J W
Br J Plast Surg. 1986 Oct;39(4):469-72. doi: 10.1016/0007-1226(86)90115-3.
This study presents further evidence of free radical involvement in skin flap necrosis in a dorsal rat flap model. Rats receiving deferoxamine, a free radical scavenger and iron chelator had significantly less necrosis (p less than 0.001) than saline treated rats. In a separate experiment, tissue determinations for malonyldialdehyde (MDA) were consistent with the survival results in showing a significant decrease in MDA in all biopsy sites (p less than 0.05 or less), indicative of reduced lipoperoxidation in the deferoxamine treated rats.
