银（I）催化的吲哚连接的炔酮的去芳构化螺环化/亲核试剂加成串联反应
Ag(I)-catalyzed dearomatizing spirocyclization/nucleophile addition cascade reactions of indole-tethered ynones.
作者信息
Bag Debojyoti, Sawant Sanghapal D
机构信息
Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu & Kashmir, 180001, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
出版信息
Chem Commun (Camb). 2023 Oct 19;59(84):12649-12652. doi: 10.1039/d3cc03543c.
Ag(I)-catalyzed highly diastereoselective construction of divergent spiroindolines is disclosed herein. The approach proceeds dearomatizing spirocyclization of indole-tethered ynones followed by C-nucleophile or hydride trapping. The established strategy is accompanied by the generation of two new C-C bonds and two contiguous stereocenters. This strategy features a broad range of (hetero)arenes as C-nucleophiles and excellent diastereoselectivity.
本文公开了银（I）催化的高度非对映选择性构建不同的螺吲哚啉。该方法通过吲哚连接的炔酮的去芳构化螺环化反应，然后进行碳亲核试剂或氢化物捕获来进行。既定策略伴随着两个新的碳-碳键和两个相邻立体中心的生成。该策略的特点是广泛的（杂）芳烃作为碳亲核试剂以及优异的非对映选择性。
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