Cardiology IV, "A.De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy.
School of Medicine and Surgery, Milano-Bicocca University, Milan, Italy.
High Blood Press Cardiovasc Prev. 2023 Sep;30(5):411-425. doi: 10.1007/s40292-023-00602-4. Epub 2023 Oct 4.
The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.
血清尿酸(UA)与心血管(CV)疾病之间的关系已经得到了广泛的评估,它被发现是全因和心血管死亡率的独立预测因子,但也是急性冠脉综合征、中风和心力衰竭的独立预测因子。同样,也有许多关于 UA 与肾功能之间关系的论文发表,而关于 UA 在代谢紊乱中的作用,特别是在代谢综合征中的作用,人们知之甚少。尽管关于这个主题的出版物很多,但仍有一些疑问:(1)用于细化 CV 风险的更好的截止值(也称为 CV 截止值);(2)UA 值需要根据肾功能进行校正;(3)更好地定义其在代谢综合征中的作用:UA 仅仅是代谢失调的标志物、旁观者还是关键的病理因素?。尿酸对心脏健康有益(URRAH)项目是由意大利高血压学会尿酸和 CV 风险工作组设计的,旨在回答第一个问题。在确定不同 CV 疾病特定截止值的第一篇论文发表后,随后又发表了一些文章来回答其他相关问题。这篇综述将总结迄今为止从 URRAH 研究项目中获得的大部分结果。
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