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URRAH(尿酸对心脏健康的作用)项目的结果:关注高尿酸血症与心血管和肾脏疾病的关系及其在代谢失调中的作用。

The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.

机构信息

Cardiology IV, "A.De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy.

School of Medicine and Surgery, Milano-Bicocca University, Milan, Italy.

出版信息

High Blood Press Cardiovasc Prev. 2023 Sep;30(5):411-425. doi: 10.1007/s40292-023-00602-4. Epub 2023 Oct 4.


DOI:10.1007/s40292-023-00602-4
PMID:37792253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10600296/
Abstract

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

摘要

血清尿酸(UA)与心血管(CV)疾病之间的关系已经得到了广泛的评估,它被发现是全因和心血管死亡率的独立预测因子,但也是急性冠脉综合征、中风和心力衰竭的独立预测因子。同样,也有许多关于 UA 与肾功能之间关系的论文发表,而关于 UA 在代谢紊乱中的作用,特别是在代谢综合征中的作用,人们知之甚少。尽管关于这个主题的出版物很多,但仍有一些疑问:(1)用于细化 CV 风险的更好的截止值(也称为 CV 截止值);(2)UA 值需要根据肾功能进行校正;(3)更好地定义其在代谢综合征中的作用:UA 仅仅是代谢失调的标志物、旁观者还是关键的病理因素?。尿酸对心脏健康有益(URRAH)项目是由意大利高血压学会尿酸和 CV 风险工作组设计的,旨在回答第一个问题。在确定不同 CV 疾病特定截止值的第一篇论文发表后,随后又发表了一些文章来回答其他相关问题。这篇综述将总结迄今为止从 URRAH 研究项目中获得的大部分结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/01145097fc78/40292_2023_602_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/da72dcd16412/40292_2023_602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/3412662e1a32/40292_2023_602_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/3cbc0969591c/40292_2023_602_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/01145097fc78/40292_2023_602_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/da72dcd16412/40292_2023_602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/3412662e1a32/40292_2023_602_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/3cbc0969591c/40292_2023_602_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9839/10600296/01145097fc78/40292_2023_602_Fig4_HTML.jpg

相似文献

[1]
The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.

High Blood Press Cardiovasc Prev. 2023-9

[2]
Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project.

High Blood Press Cardiovasc Prev. 2020-4

[3]
The URRAH study.

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[4]
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[5]
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J Nephrol. 2022-1

[6]
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Nutr Metab Cardiovasc Dis. 2022-5

[7]
Exploration into Uric and Cardiovascular Disease: Uric Acid Right for heArt Health (URRAH) Project, A Study Protocol for a Retrospective Observational Study.

High Blood Press Cardiovasc Prev. 2018-6

[8]
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[9]
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[10]
Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project.

Eur J Intern Med. 2023-8

引用本文的文献

[1]
Uric Acid in Primary Hyperparathyroidism: Marker, Consequence, or Bystander?

Metabolites. 2025-7-2

[2]
Triglyceride-glucose index threshold for cardiovascular mortality in hypertensive individuals - URRAH project.

Am J Prev Cardiol. 2025-6-29

[3]
Hyperuricemia-Especially "Metabolic Hyperuricemia"-Is Independently Associated with a Higher Risk of Steatotic Liver Disease.

Metabolites. 2025-5-28

[4]
Investigating the relationship between body mass index, hypertension, and new-onset hyperuricemia in a Chinese repeat health checkup population.

BMC Public Health. 2025-5-23

[5]
Cardiovascular-Kidney-Metabolic Syndrome: A New Paradigm in Clinical Medicine or Going Back to Basics?

J Clin Med. 2025-4-19

[6]
Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge.

Front Immunol. 2025-1-28

[7]
Asymptomatic Hyperuricemia and the Kidney: Lessons from the URRAH Study.

Metabolites. 2025-1-2

[8]
The Interplay of Systemic Inflammation and Oxidative Stress in Connecting Perirenal Adipose Tissue to Hyperuricemia in Type 2 Diabetes Mellitus: A Mediation Analysis.

J Inflamm Res. 2024-12-19

[9]
Serum Uric Acid/Serum Creatinine Ratio and Chronic Vascular Lesions on Renal Biopsy: A Retrospective Observational Study.

High Blood Press Cardiovasc Prev. 2025-3

[10]
Cardiovascular-kidney-metabolic syndrome - An integrative review.

Prog Cardiovasc Dis. 2024

本文引用的文献

[1]
Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential.

Int J Mol Sci. 2023-4-10

[2]
Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project.

Eur J Intern Med. 2023-8

[3]
Update in uric acid, hypertension, and cardiovascular diseases.

Hypertens Res. 2023-7

[4]
The global burden of metabolic disease: Data from 2000 to 2019.

Cell Metab. 2023-3-7

[5]
Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study.

Metabolites. 2023-2-7

[6]
Role of Uric Acid in Vascular Remodeling: Cytoskeleton Changes and Migration in VSMCs.

Int J Mol Sci. 2023-2-3

[7]
Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level.

Nutr Metab Cardiovasc Dis. 2023-2

[8]
Association of Serum Uric Acid With All-Cause and Cardiovascular Mortality in Diabetes.

Diabetes Care. 2023-2-1

[9]
Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values.

J Hypertens. 2023-1-1

[10]
New Way to "SCORE" Risk: Updates on the ESC Scoring System and Incorporation into ESC Cardiovascular Prevention Guidelines.

Curr Cardiol Rep. 2022-11

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