COVID-19 后/长新冠综合管理项目的纵向评估，该项目包括数字干预和个人支持：随机对照试验。

Longitudinal Evaluation of an Integrated Post-COVID-19/Long COVID Management Program Consisting of Digital Interventions and Personal Support: Randomized Controlled Trial.

机构信息

Health Psychology and Behavioural Medicine, Constructor University Bremen, Bremen, Germany.

Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.

出版信息

J Med Internet Res. 2023 Oct 4;25:e49342. doi: 10.2196/49342.

DOI:10.2196/49342

PMID:37792437

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10563866/

Abstract

BACKGROUND

The postacute COVID-19 syndrome (PACS) can be addressed with multidisciplinary approaches, including professional support and digital interventions.

OBJECTIVE

This research aimed to test whether patients who received a health care facilitation program including medical internet support from human personal pilots and digital interventions (intervention group [IG] and active control group [ACG]) would experience fewer symptoms and have higher work ability and social participation than an untreated comparison group (CompG). The second objective was to compare the impact of a diagnostic assessment and digital interventions tailored to patients' personal capacity (IG) with that of only personal support and digital interventions targeting the main symptoms (ACG).

METHODS

In total, 1020 patients with PACS were recruited. Using a randomized controlled trial design between the IG and the ACG, as well as propensity score matching to include the CompG, analyses were run with logistic regression and hierarchical-linear models.

RESULTS

Symptoms decreased significantly in all groups over time (βT1-T2=0.13, t=5.67, P<.001; βT2-T4=0.06, t=2.83, P=.01), with a main effect of the group (β=-.15, t=-2.65, P=.01) and a more pronounced effect in the IG and ACG compared to the CompG (between groups: βT1-T2=0.14, t=4.31, P<.001; βT2-T4=0.14, t=4.57, P<.001). Work ability and social participation were lower in the CompG, but there was no significant interaction effect. There were no group differences between the IG and the ACG.

CONCLUSIONS

Empowerment through personal pilots and digital interventions reduces symptoms but does not increase work ability and social participation. More longitudinal research is needed to evaluate the effects of a diagnostic assessment. Social support and digital interventions should be incorporated to facilitate health care interventions for PACS.

TRIAL REGISTRATION

ClinicalTrials.gov NCT05238415; https://classic.clinicaltrials.gov/ct2/show/NCT05238415.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1186/s12879-022-07584-z.

摘要

背景

新冠后综合征（PACS）可以通过多学科方法治疗，包括专业支持和数字干预。

目的

本研究旨在测试接受包括医疗互联网支持在内的健康促进计划的患者（干预组 [IG] 和主动对照组 [ACG]）与未经治疗的对照组（CompG）相比，症状是否更少，工作能力和社会参与度是否更高。第二个目标是比较针对患者个人能力的诊断评估和数字干预（IG）与仅针对主要症状的个人支持和数字干预（ACG）的影响。

方法

共招募了 1020 名 PACS 患者。采用 IG 和 ACG 之间的随机对照试验设计，以及倾向评分匹配纳入 CompG，使用逻辑回归和层次线性模型进行分析。

结果

所有组的症状随时间显著下降（βT1-T2=0.13，t=5.67，P<.001；βT2-T4=0.06，t=2.83，P=.01），具有组的主要效应（β=-.15，t=-2.65，P=.01），IG 和 ACG 比 CompG 的效果更明显（组间：βT1-T2=0.14，t=4.31，P<.001；βT2-T4=0.14，t=4.57，P<.001）。CompG 的工作能力和社会参与度较低，但无显著交互作用。IG 和 ACG 之间没有组间差异。