Levine J D, Rosenwasser A M, Yanovski J A, Adler N T
Brain Res. 1986 Oct 8;384(2):240-9. doi: 10.1016/0006-8993(86)91160-1.
The dorsal and median mesencephalic raphe nuclei provide a robust projection to the hypothalamic suprachiasmatic nucleus, the site of a putative neuronal circadian pacemaker. Although it has been suggested that the raphe may play a role in the circadian timing system, this role has not yet been specified. In the present report, we examined the circadian activity patterns of rats with large mid-brain lesions aimed at the median and dorsal raphe nuclei under conditions of light-dark entrainment, and while free-running in constant light and constant darkness. The results indicate that midbrain raphe lesions may interfere with the expression of free-running circadian activity rhythms.
中脑背侧和中缝核向丘脑下部视交叉上核发出大量投射，视交叉上核被认为是神经元昼夜节律起搏器所在部位。尽管有人提出中缝核可能在昼夜节律系统中起作用，但这一作用尚未明确。在本报告中，我们研究了在明暗交替诱导条件下以及在持续光照和持续黑暗中自由活动时，患有针对中缝背核和中缝核的大面积中脑损伤的大鼠的昼夜活动模式。结果表明，中脑缝际核损伤可能会干扰自由活动的昼夜节律活动的表达。
