Kim Honey, Baek Seon-Hwa, Kim Ju-Wan, Ryu Seunghyong, Lee Ju-Yeon, Kim Jae-Min, Chung Young-Chul, Kim Sung-Wan
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
Mindlink, Gwangju Bukgu Community Mental Health and Welfare Center, Gwangju, Korea.
Schizophrenia (Heidelb). 2023 Oct 4;9(1):68. doi: 10.1038/s41537-023-00398-1.
Neuroinflammation contributes to the pathophysiology of various mental illnesses including schizophrenia. We investigated peripheral inflammatory cytokines as a biomarker for predicting symptomatic remission in patients with first-episode schizophrenia. The study included 224 patients aged 15-60 years who fulfilled the criteria for schizophrenia spectrum disorder with a treatment duration ≤6 months. Serum levels of tumor necrosis factor (TNF) -α, interferon-γ, interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, and IL-12 were measured. Psychotic symptoms, depressive symptoms, and general functioning were assessed using the Positive and Negative Syndrome Scale, Beck Depression Inventory (BDI), Calgary Depression Scale for Schizophrenia, and Personal and Social Performance scale, respectively. Duration of untreated psychosis (DUP) was also recorded. We investigated the factors associated with remission for each sex in logistic regression analysis. In total, 174 patients achieved remission at the 6-month follow-up (females, 83.5%; males, 70.9%). Remission was associated with older age and lower BDI scores in male patients and with lower TNF-α levels and shorter DUP in female patients. Our findings suggest that peripheral inflammatory cytokines may impede early symptomatic remission in female patients with schizophrenia. In addition, depressive symptoms in males and long DUP in females may be poor prognostic factors for early remission in patients with first-episode psychosis.
神经炎症在包括精神分裂症在内的多种精神疾病的病理生理过程中起作用。我们研究了外周炎性细胞因子作为首发精神分裂症患者症状缓解预测生物标志物的情况。该研究纳入了224名年龄在15至60岁之间、符合精神分裂症谱系障碍标准且治疗时间≤6个月的患者。检测了血清中肿瘤坏死因子（TNF）-α、干扰素-γ、白细胞介素（IL）-1α、IL-1β、IL-6、IL-8、IL-10和IL-12的水平。分别使用阳性和阴性症状量表、贝克抑郁量表（BDI）、精神分裂症卡尔加里抑郁量表以及个人和社会表现量表评估精神病性症状、抑郁症状和总体功能。还记录了未治疗精神病的持续时间（DUP）。在逻辑回归分析中，我们研究了与每种性别缓解相关的因素。总共174名患者在6个月随访时实现缓解（女性，83.5%；男性，70.9%）。男性患者缓解与年龄较大和BDI得分较低相关，女性患者缓解与TNF-α水平较低和DUP较短相关。我们的研究结果表明，外周炎性细胞因子可能会阻碍女性精神分裂症患者的早期症状缓解。此外，男性的抑郁症状和女性的较长DUP可能是首发精神病患者早期缓解的不良预后因素。
