Cabana T, Martin G F
Brain Res. 1986 Nov;395(1):1-11. doi: 10.1016/s0006-8993(86)80002-6.
We have employed the orthograde transport of wheat germ agglutinin conjugated to horseradish peroxidase to study the organization of rubrospinal connections in adult and pouch young opossums. Our results suggest that: in the adult opossum rubrospinal axons are distributed more widely than suggested by previous studies; rubrospinal projections are formed postnatally in the opossum, but much earlier than corticospinal connections; rubrospinal axons do not grow synchronously, as a massive bundle following a few leading axons, but by addition of axons over a protracted period of time; and the growth of rubral axons into the spinal gray matter follows a predictable rostral to caudal gradient as well as a proximal to distal one relative to the tract. Rubrospinal development is discussed in light of the growth of cerebellar and cortical axons into the red nucleus and the development of motor function.
我们利用与辣根过氧化物酶结合的小麦胚凝集素的顺行运输来研究成年和幼龄负鼠红核脊髓连接的组织情况。我们的结果表明：在成年负鼠中，红核脊髓轴突的分布比先前研究所显示的更为广泛；负鼠的红核脊髓投射在出生后形成，但比皮质脊髓连接要早得多；红核脊髓轴突并非像大量轴突跟随少数领先轴突那样同步生长，而是在一段较长时间内通过轴突的添加而生长；并且红核轴突向脊髓灰质的生长遵循从吻侧到尾侧的可预测梯度以及相对于束从近端到远端的梯度。根据小脑和皮质轴突向红核的生长以及运动功能的发育来讨论红核脊髓的发育。
