Department of Otorhinolaryngology, Bursa Uludağ University, Bursa, Turkey.
Department of Pathology, Bursa Uludağ University, Bursa, Turkey.
Niger J Clin Pract. 2023 Sep;26(9):1303-1308. doi: 10.4103/njcp.njcp_36_23.
In early-stage lip cancer, spread to cervical lymph nodes is extremely rare. Elective neck treatment options include suprahyoid or supraomohyoid neck dissection, sentinel lymph node biopsy, or close follow-up. Aim: In this study, our aim was to investigate the effect of elective surgery on survival in patients operated for early-stage lip cancer.
Patients who underwent surgical treatment for lower lip squamous cell carcinoma between 2005 and 2020 were retrospectively analyzed. Age, gender, neck dissection status (yes/no), clinical and pathological T stage of the tumor, grade, and perineural invasion were recorded and 3-year and 5-year overall (OS) and disease-free survival (DFS) rates were estimated.
Thirty patients were included: 20 patients had pT1 and 10 patients had pT2 tumors. Neck dissection was performed in 13 patients. The 5-year OS rate was 90.9% and 87.8% with and without dissection, respectively. Neck dissection did not appear to affect OS (P = 0.534) in these patients. The 5-year DFS rate was 96.4% in the overall group, while it was 91.7% and 100% in patients who did or did not undergo neck dissection, respectively (P = 0.756).
Patients with or without neck dissection did not differ significantly in terms of OS and DFS. Watchful waiting with regular ultrasound imaging of the neck in patients with T1 and T2 lip tumors may be an appropriate therapeutic option.
在早期唇癌中，颈部淋巴结转移极为罕见。颈淋巴结处理的选择包括颏下或颌下颈清扫术、前哨淋巴结活检或密切随访。目的：本研究旨在探讨选择性手术对早期唇癌患者生存的影响。
回顾性分析 2005 年至 2020 年间接受手术治疗的下唇鳞状细胞癌患者。记录年龄、性别、颈清扫情况（有/无）、肿瘤临床和病理 T 分期、分级和神经周围侵犯情况，并估计 3 年和 5 年总生存（OS）和无病生存（DFS）率。
共纳入 30 例患者：20 例为 pT1 期，10 例为 pT2 期。13 例患者行颈清扫术。有/无颈清扫术的 5 年 OS 率分别为 90.9%和 87.8%。颈清扫术对这些患者的 OS 似乎没有影响（P=0.534）。总体 5 年 DFS 率为 96.4%，而行/不行颈清扫术的患者分别为 91.7%和 100%（P=0.756）。
有/无颈清扫术的患者在 OS 和 DFS 方面无显著差异。对于 T1 和 T2 唇肿瘤患者，定期行颈部超声检查并密切观察可能是一种合适的治疗选择。
