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More than a lonca-shot: beating the odds in relapsed/ refractory diffuse large B-cell lymphoma.

作者信息

Ho Carrie, Smith Stephen D

机构信息

Division of Hematology and Oncology, Department of Internal Medicine, University of Washington, Seattle, WA, USA; Fred Hutchinson Cancer Center, Seattle, WA.

出版信息

Haematologica. 2024 Apr 1;109(4):1022-1024. doi: 10.3324/haematol.2023.284056.

DOI:10.3324/haematol.2023.284056
PMID:37794796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10985445/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b2/10985445/66ba51e8250e/1091022.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b2/10985445/66ba51e8250e/1091022.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61b2/10985445/66ba51e8250e/1091022.fig1.jpg

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本文引用的文献

1
Targeting CD19-positive lymphomas with the antibodydrug conjugate loncastuximab tesirine: preclinical evidence of activity as a single agent and in combination therapy.用抗体药物偶联物 loncastuximab tesirine 靶向 CD19 阳性淋巴瘤:作为单一药物和联合治疗的临床前活性证据。
Haematologica. 2024 Oct 1;109(10):3314-3326. doi: 10.3324/haematol.2023.284197.
2
Loncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma: long-term efficacy and safety from the phase II LOTIS-2 study.Loncastuximab tesirine 治疗复发/难治性弥漫性大 B 细胞淋巴瘤:来自 II 期 LOTIS-2 研究的长期疗效和安全性。
Haematologica. 2024 Apr 1;109(4):1184-1193. doi: 10.3324/haematol.2023.283459.
3
Epcoritamab, a Novel, Subcutaneous CD3xCD20 Bispecific T-Cell-Engaging Antibody, in Relapsed or Refractory Large B-Cell Lymphoma: Dose Expansion in a Phase I/II Trial.
依帕珠单抗,一种新型皮下注射 CD3xCD20 双特异性 T 细胞接合抗体,用于治疗复发/难治性大 B 细胞淋巴瘤:一项 I/II 期试验的剂量扩展。
J Clin Oncol. 2023 Apr 20;41(12):2238-2247. doi: 10.1200/JCO.22.01725. Epub 2022 Dec 22.
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Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma.戈利木单抗治疗复发/难治性弥漫性大 B 细胞淋巴瘤。
N Engl J Med. 2022 Dec 15;387(24):2220-2231. doi: 10.1056/NEJMoa2206913. Epub 2022 Dec 11.
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Loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma (LOTIS-2): a multicentre, open-label, single-arm, phase 2 trial.Loncastuximab tesirine 治疗复发或难治性弥漫性大 B 细胞淋巴瘤(LOTIS-2):一项多中心、开放标签、单臂、2 期临床试验。
Lancet Oncol. 2021 Jun;22(6):790-800. doi: 10.1016/S1470-2045(21)00139-X. Epub 2021 May 11.
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Lancet Oncol. 2020 Jul;21(7):978-988. doi: 10.1016/S1470-2045(20)30225-4. Epub 2020 Jun 5.
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Blood. 2015 Feb 26;125(9):1394-402. doi: 10.1182/blood-2014-09-598763. Epub 2015 Jan 8.