母乳中的液体活检用于乳腺癌的早期检测。

Liquid Biopsies in Breast Milk for the Early Detection of Breast Cancer.

机构信息

Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom.

Ralph Lauren Centre for Breast Cancer Research and Breast Unit, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.

出版信息

Cancer Discov. 2023 Oct 5;13(10):2125-2127. doi: 10.1158/2159-8290.CD-23-0836.

DOI:10.1158/2159-8290.CD-23-0836

PMID:37794840

Abstract

Cell-free tumor DNA has previously been detected in nonblood sources, including urine, saliva, stool, cerebrospinal fluid, and pleural fluid. In this issue, Saura and colleagues present a novel proof-of-concept study demonstrating that detection of tumor DNA in breast milk is feasible and may be a potential future strategy to screen for postpartum breast cancer. See related article by Saura et al., p. 2180 (14).

摘要

先前已有研究在非血液来源中检测到游离肿瘤 DNA，包括尿液、唾液、粪便、脑脊液和胸腔积液。在本期中，Saura 等人提出了一项新颖的概念验证研究，表明在母乳中检测肿瘤 DNA 是可行的，并且可能是一种潜在的产后乳腺癌筛查策略。见 Saura 等人的相关文章，第 2180 页（14）。