通过三氟甲磺酸镧催化的3,4-环氧胺的分子内区域选择性氨解反应合成氮杂环丁烷。
Azetidine synthesis by La(OTf)-catalyzed intramolecular regioselective aminolysis of -3,4-epoxy amines.
作者信息
Kuriyama Yuse, Sasano Yusuke, Iwabuchi Yoshiharu
机构信息
Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
出版信息
Front Chem. 2023 Sep 19;11:1251299. doi: 10.3389/fchem.2023.1251299. eCollection 2023.
Abstract
Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)-catalyzed intramolecular regioselective aminolysis of -3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups.
摘要
氮杂环丁烷是在各种生物活性化合物中发现的一种常见结构单元。在本研究论文中，我们报道了三氟甲磺酸镧催化的 -3,4-环氧胺的分子内区域选择性氨解反应，以生成氮杂环丁烷。即使在存在酸敏感和路易斯碱性官能团的情况下，该反应也能高产率地进行。
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