Locati Laura D, Ferrarotto Renata, Licitra Lisa, Benazzo Marco, Preda Lorenzo, Farina Davide, Gatta Gemma, Lombardi Davide, Nicolai Piero, Vander Poorten Vincent, Chua Melvin Lee Kiang, Vischioni Barbara, Sanguineti Giuseppe, Morbini Patrizia, Fonseca Isabel, Sozzi Davide, Merlotti Anna, Orlandi Ester
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Medical Oncology Unit, Istituti Clinici Scientifici Maugeri Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pavia, Italy.
Front Oncol. 2023 Sep 19;13:1264287. doi: 10.3389/fonc.2023.1264287. eCollection 2023.
Salivary gland cancers (SGCs) are rare, accounting for less than 5% of all malignancies of the head and neck region, and are morphologically heterogeneous. The diagnosis is mainly based on histology, with the complementary aid of molecular profiling, which is helpful in recognizing some poorly differentiated, borderline, or atypical lesions. Instrumental imaging defines the diagnosis, representing a remarkable tool in the treatment plan. Ultrasound and magnetic resonance are the most common procedures used to describe the primary tumour. The treatment of SGCs is multimodal and consists of surgery, radiotherapy, and systemic therapy; each treatment plan is, however, featured on the patient and disease's characteristics. On 24 June 2022, in the meeting "Current management and future challenges in salivary gland cancers" many experts in this field discussed the state of the art of SGCs research, the future challenges and developments. After the meeting, the same pool of experts maintained close contact to keep these data further updated in the conference proceedings presented here. This review collects the insights and suggestions that emerged from the discussion during and after the meeting per se.
涎腺癌(SGCs)较为罕见,占头颈部所有恶性肿瘤的比例不到5%,且形态学上具有异质性。诊断主要基于组织学,并辅以分子谱分析,这有助于识别一些低分化、临界或非典型病变。影像学检查确定诊断,是治疗计划中的一项重要工具。超声和磁共振是描述原发性肿瘤最常用的检查方法。SGCs的治疗是多模式的,包括手术、放疗和全身治疗;然而,每个治疗方案都根据患者和疾病的特征制定。2022年6月24日,在“涎腺癌的当前管理和未来挑战”会议上,该领域的许多专家讨论了SGCs研究的现状、未来挑战和发展。会议结束后,同一批专家保持密切联系,以便在本文所展示的会议记录中进一步更新这些数据。本综述收集了会议期间及之后讨论中产生的见解和建议。