Faculty of Medicine, Saint Joseph University of Beirut, Lebanon.
Faculty of Medicine, American University of Beirut, Lebanon.
Future Oncol. 2023 Sep;19(29):1991-2002. doi: 10.2217/fon-2023-0535. Epub 2023 Oct 5.
Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values - mainly immunoglobulin heavy chain variable region gene () mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Prominent IGHV genes were , and ; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. The distribution of alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis.
慢性淋巴细胞白血病（CLL）是一种高度异质性的血液病。对 CLL 患者进行基因分层具有重要的预后和治疗价值——主要是免疫球蛋白重链可变区（IGHV）基因的突变状态和细胞遗传学异常。黎巴嫩 CLL 的遗传学在文献中鲜有描述。在这项工作中，我们研究了 312 名黎巴嫩 CLL 患者的遗传生物标志物。突出的 IGHV 基因有、和；CLL #1 和 #5 呈现主要亚群。与先前发表的数据相比，我们的数据显示出一些相似之处和主要差异。我们系列中等位基因的分布与先前描述的分布不同，这表明抗原选择和 CLL 发病机制中的区域变量参与其中。
