OBJECTIVE: To study the general patterns and differences in the macroscopic structure of Broca's motor speech area in the left and right hemispheres of male and female brains. MATERIAL AND METHODS: The study was conducted on MRI images of the brains of 9 men and 9 women (36 hemispheres in total). All the people were between the ages of 20 and 30, without any mental or neurological disorders. The localization and structure of the main sulci and gyri of Broca's area, namely the pars triangularis and pars opercularis, were studied. In addition, the topography of the main sulci in Broca's motor speech area, namely their shape, length, and relative position to the other sulci, was analyzed. RESULTS: The features of the localization of the sulci in Broca's area, the differences in the number of additional sulci in the pars triangularis and pars opercularis of male and female brains, as well as the degree of asymmetry of Broca's area in the left and right hemispheres of the brains of men and women were established.In modern neuroscience a new scientific direction of genderology, which studies the behavior and cognitive functions of males and females, is rapidly developing. CONCLUSION: Broca's motor speech area of the brain of men and women differs in macroscopic structure.