Scheid V, Buzdar A U, Smith T L, Hortobagyi G N
Cancer. 1986 Dec 15;58(12):2589-93. doi: 10.1002/1097-0142(19861215)58:12<2589::aid-cncr2820581206>3.0.co;2-o.
Between July 1973 and December 1979, 1171 patients with metastatic breast cancer were treated with doxorubicin-containing chemotherapy. Of those patients, 195 had osseous metastases only. Upon initial diagnosis, 48% had osteolytic metastases; 13% had osteoblastic metastases; 38% had mixed metastases; and 1% had diffuse osteoporosis without any obvious bone destruction. The most common sites of involvement were the dorsal spine (62%), lumbosacral spine (72%), and pelvis (79%). Objective response to chemotherapy was observed in 59% of patients; complete responses were noted in 7%, and partial responses in 52%. The median survival was 28 months (range, 1-118 months). The median time lapse between the start of chemotherapy and disease progression was 14 months (range, 1-109 months). In 32 patients who responded to the treatment, chemotherapy was discontinued after 2 years, and their median duration of continued remission at 39 and 75 months after the completion of therapy. The incidence of pathological fractures was 57%; the most common sites were the spine, which sustained compression fractures, and the ribs. The incidences of hypercalcemia and spinal cord compression due to metastases were 19% and 10%, respectively.
1973年7月至1979年12月期间，1171例转移性乳腺癌患者接受了含阿霉素的化疗。在这些患者中，195例仅发生骨转移。初诊时，48%为溶骨性转移；13%为成骨性转移；38%为混合性转移；1%为弥漫性骨质疏松，无明显骨质破坏。最常受累的部位是胸椎（62%）、腰骶椎（72%）和骨盆（79%）。59%的患者对化疗有客观反应；7%为完全缓解，52%为部分缓解。中位生存期为28个月（范围1 - 118个月）。化疗开始至疾病进展的中位时间为14个月（范围1 - 109个月）。32例对治疗有反应的患者在2年后停止化疗，其治疗完成后持续缓解的中位持续时间分别为39个月和75个月。病理性骨折的发生率为57%；最常见的部位是发生压缩性骨折的脊柱和肋骨。转移引起的高钙血症和脊髓压迫的发生率分别为19%和10%。
