From the Department of Ophthalmology, University of Michigan, Ann Arbor, MI.
Department of Economics.
Cancer J. 2023;29(5):279-284. doi: 10.1097/PPO.0000000000000683.
The liver is a common site of metastasis for many primary malignancies, but the quantitative impact on survival is unknown. We performed a systematic review and meta-analysis of 83 studies (604,853 patients) assessing the overall hazard associated with liver metastases by primary tumor type and treatment regimen. The pooled overall survival hazard ratio (HR) for all included studies was 1.77 (95% confidence interval [CI], 1.62-1.93). Patients with breast cancer primaries fared the worst (HR, 2.37; 95% CI, 1.64-3.44), as did patients treated with immunotherapies (HR, 1.86; 95% CI, 1.42-2.42). Liver metastases negatively impact survival, necessitating new approaches to disease management.
肝脏是许多原发性恶性肿瘤转移的常见部位，但对生存的定量影响尚不清楚。我们对 83 项研究（604853 名患者）进行了系统评价和荟萃分析，评估了按原发性肿瘤类型和治疗方案分类的肝转移的总体风险。所有纳入研究的总体生存风险比（HR）为 1.77（95%置信区间 [CI]，1.62-1.93）。乳腺癌原发患者的预后最差（HR，2.37；95% CI，1.64-3.44），接受免疫治疗的患者也如此（HR，1.86；95% CI，1.42-2.42）。肝转移对生存有负面影响，需要新的疾病管理方法。
