He Xiangqiong, Shi Pengbao, Wu Taixia, Yu Bing, Cong Hailin, Shen Youqing
College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China.
State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China.
ACS Appl Mater Interfaces. 2023 Oct 18;15(41):48660-48672. doi: 10.1021/acsami.3c10788. Epub 2023 Oct 5.
Transmission through the respiratory tract is one of the most important ways for bacteria and viruses to infect the human body; the use of high-performance antibacterial and antiviral protective equipment is the most effective way to prevent the spread of respiratory diseases. However, at present, most personal protective equipment lacks the ability to kill pathogens. In this paper, a kind of polytetrahydropyrimidine-polyethylene terephthalate functional fiber (PET-PTHP fibers) with highly sustained antibacterial and antiviral properties was prepared. The inactivation rate of the fibers against and was as high as 99.99%, and the antibacterial time was more than 72 h. The fibers have an obvious destructive effect on lentiviruses and can reduce the infection rate of lentiviruses in BxPC-3 cells from 25.4 to 9.7%. The cytotoxicity test, cell live/dead staining test, and cell proliferation test all confirmed that PET-PTHP fibers have no obvious cytotoxicity and good cytocompatibility. By applying the functional fibers to the inner layer of the masks, a new type of mask with adsorption, filtration, and killing properties against pathogens was prepared. The filtration efficiency of the new masks was 99.3%, and the pressure drop was 104 Pa. The new masks have excellent air permeability and filtration effect, meet the practical application conditions, and are of grade A; therefore, these masks provide medical protection as well as kill pathogens at the same time, further reducing the risk of human infection.
通过呼吸道传播是细菌和病毒感染人体的最重要途径之一；使用高性能抗菌和抗病毒防护装备是预防呼吸道疾病传播的最有效方法。然而，目前大多数个人防护装备缺乏杀灭病原体的能力。本文制备了一种具有高度持久抗菌和抗病毒性能的聚四氢嘧啶 - 聚对苯二甲酸乙二酯功能纤维（PET - PTHP纤维）。该纤维对[具体病毒名称1]和[具体病毒名称2]的灭活率高达99.99%，抗菌时间超过72小时。该纤维对慢病毒有明显的破坏作用，可将慢病毒在BxPC - 3细胞中的感染率从25.4%降至9.7%。细胞毒性试验、细胞活/死染色试验和细胞增殖试验均证实PET - PTHP纤维无明显细胞毒性且具有良好的细胞相容性。通过将功能纤维应用于口罩内层，制备了一种对病原体具有吸附、过滤和杀灭性能的新型口罩。新型口罩的过滤效率为99.3%，压降为104 Pa。新型口罩具有优异的透气性和过滤效果，满足实际应用条件，等级为A级；因此，这些口罩在提供医疗防护的同时还能杀灭病原体，进一步降低人类感染风险。
