Department of Psychiatry, University of Pittsburgh, USA.
Psychiatry Res. 2023 Nov;329:115521. doi: 10.1016/j.psychres.2023.115521. Epub 2023 Oct 1.
This article describes the progress that my colleagues and I have made over the last two decades in building a clinical neuroscience research program in Bipolar Disorder (BD). Here, we have focused on key research themes to ultimately help with early risk detection and the development of better treatments for individuals with BD. We have described the main areas that we are pursuing, namely, understanding the underlying neural mechanisms of BD and BD risk, differentiating BD and BD risk from depressive disorder risk, and the development of new treatments for individuals with BD. We conclude with a summary of future directions in our research that include examination of the molecular and metabolic abnormalities associated with neural network abnormalities underlying mania/hypomania risk, testing neural risk markers in independent samples stratified according to familial risk for BD, and the study of early infant and child neurodevelopmental processes that confer risk for affective disorders, including BD, in order to elucidate early neural risk markers.
本文描述了我和同事在过去二十年中在双相情感障碍（BD）临床神经科学研究项目中取得的进展。在这里，我们专注于关键的研究主题，最终帮助早期风险检测和为 BD 患者开发更好的治疗方法。我们描述了我们正在追求的主要领域，即了解 BD 和 BD 风险的潜在神经机制，将 BD 和 BD 风险与抑郁障碍风险区分开来，以及为 BD 患者开发新的治疗方法。我们总结了我们研究的未来方向，包括检查与躁狂/轻躁狂风险相关的神经网络异常的分子和代谢异常，根据 BD 的家族风险对独立样本进行神经风险标志物测试，以及研究婴儿和儿童神经发育过程，这些过程为包括 BD 在内的情感障碍带来风险，以阐明早期神经风险标志物。
