Dent Elsa, Hanlon Peter, Sim Marc, Jylhävä Juulia, Liu Zuyun, Vetrano Davide L, Stolz Erwin, Pérez-Zepeda Mario Ulises, Crabtree Daniel R, Nicholson Caroline, Job Jenny, Ambagtsheer Rachel C, Ward Paul R, Shi Sandra M, Huynh Quan, Hoogendijk Emiel O
Research Centre for Public Health, Equity and Human Flourishing, Torrens University Australia, Adelaide, Australia.
School of Health and Wellbeing, University of Glasgow, Scotland, UK.
Ageing Res Rev. 2023 Nov;91:102082. doi: 10.1016/j.arr.2023.102082. Epub 2023 Oct 4.
Frailty is an age-related clinical condition characterised by an increased susceptibility to stressors and an elevated risk of adverse outcomes such as mortality. In the light of global population ageing, the prevalence of frailty is expected to soar in coming decades. This narrative review provides critical insights into recent developments and emerging practices in frailty research regarding identification, management, risk factors, and prevention. We searched journals in the top two quartiles of geriatrics and gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 and 20 December 2022. Several recent developments were identified, including new biomarkers and biomarker panels for frailty screening and diagnosis, using artificial intelligence to identify frailty, and investigating the altered response to medications by older adults with frailty. Other areas with novel developments included exercise (including technology-based exercise), multidimensional interventions, person-centred and integrated care, assistive technologies, analysis of frailty transitions, risk-factors, clinical guidelines, COVID-19, and potential future treatments. This review identified a strong need for the implementation and evaluation of cost-effective, community-based interventions to manage and prevent frailty. Our findings highlight the need to better identify and support older adults with frailty and involve those with frailty in shared decision-making regarding their care.
衰弱是一种与年龄相关的临床状况，其特征是对应激源的易感性增加以及诸如死亡等不良后果的风险升高。鉴于全球人口老龄化，预计衰弱的患病率在未来几十年将急剧上升。本叙述性综述对衰弱研究在识别、管理、风险因素和预防方面的最新进展和新兴实践提供了重要见解。我们检索了老年医学和老年学领域前两个四分位数的期刊（来自科睿唯安期刊引证报告），查找2018年1月1日至2022年12月20日期间发表的文章。确定了一些近期进展，包括用于衰弱筛查和诊断的新生物标志物和生物标志物组合、使用人工智能识别衰弱以及研究衰弱老年人对药物的反应改变。其他有新进展的领域包括运动（包括基于技术的运动）、多维度干预、以人为主的综合护理、辅助技术、衰弱转变分析、风险因素、临床指南、COVID-19以及潜在的未来治疗方法。本综述确定了对实施和评估具有成本效益的基于社区的干预措施以管理和预防衰弱的强烈需求。我们的研究结果强调了更好地识别和支持衰弱老年人并让衰弱者参与有关其护理的共同决策的必要性。
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