Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Winnipeg Health Sciences Centre, Winnipeg, MB, Canada; University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada.
Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Brain Res Bull. 2023 Oct 15;203:110771. doi: 10.1016/j.brainresbull.2023.110771. Epub 2023 Oct 4.
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by inflammation of the gastrointestinal tract and is a disorder of the brain-gut axis. Neuroimaging studies of brain function and structure have helped better understand the relationships between the brain, gut, and comorbidity in IBD. Studies of brain structure have primarily employed voxel-based morphometry to measure grey matter volume and surface-based morphometry to measure cortical thickness. Far fewer studies have employed other surface-based morphometry metrics such as gyrification, cortical complexity, and sulcal depth. In this study, brain structure differences between 72 adults with IBD and 90 healthy controls were assessed using all five metrics. Significant differences were found for cortical thickness with the IBD group showing extensive left-lateralized thinning, and for cortical complexity with the IBD group showing greater complexity in the left fusiform and right posterior cingulate. No significant differences were found in grey matter volume, gyrification, or sulcal depth. Within the IBD group, a post hoc analysis identified that disease duration is associated with cortical complexity of the right supramarginal gyrus, albeit with a more lenient threshold applied.
炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），其特征为胃肠道炎症，是脑肠轴紊乱的一种。对大脑功能和结构的神经影像学研究有助于更好地理解 IBD 中大脑、肠道和合并症之间的关系。对大脑结构的研究主要采用体素形态计量学来测量灰质体积，以及基于表面的形态计量学来测量皮质厚度。采用其他基于表面的形态计量学指标（如脑回形成、皮质复杂度和脑沟深度）的研究则少得多。在这项研究中，使用所有五个指标评估了 72 名 IBD 成年人和 90 名健康对照者的大脑结构差异。发现皮质厚度存在显著差异，IBD 组表现为广泛的左侧变薄，皮质复杂度存在显著差异，IBD 组左侧梭状回和右侧后扣带回的复杂度更大。灰质体积、脑回形成和脑沟深度没有显著差异。在 IBD 组中，一项事后分析发现，疾病持续时间与右侧缘上回的皮质复杂度有关，尽管应用了更宽松的阈值。
