Public Health School, Mudanjiang Medical University, Mudanjiang, China.
The Affiliated Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China.
Nutr Metab Cardiovasc Dis. 2023 Dec;33(12):2464-2470. doi: 10.1016/j.numecd.2023.07.038. Epub 2023 Aug 2.
Hyperuricemia has become a vital public health problem affecting the health of residents. The visceral fat area (VFA) is closely related to many chronic diseases. However, the association between VFA and hyperuricemia within the Chinese adult population remains nebulous. The aim of the research is to assess the relationship between VFA and serum uric acid levels.
From June 2020 to June 2021, a total of 340 Chinese adults (240 in the control group and 100 in the hyperuricemia group) were recruited from the physical examination center of Hongqi Hospital Affiliated to Mudanjiang Medical University. General demographic characteristics were collected by questionnaire. VFA was measured by a body composition analyzer, and serum biochemical indices were detected by clinical laboratory. VFA in the hyperuricemia group was higher than in the control group (P＜0.05). Further, VFA demonstrated a positive correlation with serum uric acid level (r = 0.370, P＜0.001). To further explore this relationship, we divided the VFA into quartiles (＜P, P-P, P-P, ≥P). Upon comparison with the ＜P group, we found the VFA in the P-P, P-P, and ≥P groups to be associated with a substantially escalated risk of hyperuricemia, even after adjusting for age, gender, body weight, fasting plasma glucose, calcium, alanine transaminase, urea, alkaline phosphatase, and γ-glutamyltransferase. The OR and 95% CI were 2.547 (1.023, 6.341), 3.788 (1.409, 10.187) and 3.723 (1.308, 10.595), respectively (P＜0.05).
VFA has a positive correlation with serum uric acid levels and may serve as a crucial predictive marker for hyperuricemia.
高尿酸血症已成为影响居民健康的重要公共卫生问题。内脏脂肪面积（VFA）与许多慢性疾病密切相关。然而，VFA 与中国成年人群血尿酸水平之间的关系仍不清楚。本研究旨在评估 VFA 与血清尿酸水平之间的关系。
2020 年 6 月至 2021 年 6 月，我们从牡丹江医学院红旗医院体检中心共招募了 340 名中国成年人（对照组 240 人，高尿酸血症组 100 人），通过问卷调查收集一般人口统计学特征。使用人体成分分析仪测量 VFA，使用临床实验室检测血清生化指标。高尿酸血症组的 VFA 高于对照组（P＜0.05）。此外，VFA 与血清尿酸水平呈正相关（r=0.370，P＜0.001）。为了进一步探讨这种关系，我们将 VFA 分为四等分（＜P、P-P、P-P、≥P）。与＜P 组相比，我们发现 P-P、P-P 和≥P 组的 VFA 与高尿酸血症的风险显著增加相关，即使在调整了年龄、性别、体重、空腹血糖、钙、丙氨酸氨基转移酶、尿素、碱性磷酸酶和γ-谷氨酰转移酶后也是如此。OR 和 95%CI 分别为 2.547（1.023，6.341）、3.788（1.409，10.187）和 3.723（1.308，10.595）（P＜0.05）。
VFA 与血清尿酸水平呈正相关，可能是高尿酸血症的重要预测标志物。
