Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, Iran.
Sharif Energy, Water and Environment Institute (SEWEI), Sharif University of Technology, P.O. Box 11155-8639, Tehran, Iran.
Sci Rep. 2023 Oct 5;13(1):16803. doi: 10.1038/s41598-023-44034-5.
An electrochemical sensory platform is presented for determination of sumatriptan (SUM) in aqueous solutions and human blood serum. A pencil graphite electrode (PGE) was electrochemically delaminated by cyclic voltammetry technique, and then further modified using nanoparticles of a zinc-based metal-organic framework (Zn(II)-MOF). The fabricated Zn(II)-MOF/EDPGE electrode was utilized for sensitive electrochemical detection of SUM via an electro-oxidation reaction. The Zn(II)-MOF was hydrothermally synthesized and characterized by various techniques. The electrochemical delamination of PGE results in a porous substrate, facilitating the effective immobilization of the modifier. The designed sensor benefits from both enhanced surface area and an accelerated electron transfer rate, as evidenced by the chronocoulogram and Nyquist plots. Under optimized conditions, the developed sensor exhibited a linear response for 0.99-9.52 µM SUM solutions. A short response time of 5 s was observed for the fabricated sensor and the detection limit was found to be 0.29 μM. Selectivity of Zn(II)-MOF/EDPGE towards SUM was evaluated by examining the interference effect of codeine, epinephrine, acetaminophen, ascorbic acid, and uric acid, which are commonly found in biological samples. The developed sensor shows excellent performance with recovery values falling within the range of 96.6 to 111% for the analysis of SUM in human blood serum samples.
电化学传感平台用于测定水溶液和人血清中的舒马曲坦（SUM）。通过循环伏安法电化学分层处理铅笔芯石墨电极（PGE），然后进一步使用基于锌的金属有机骨架（Zn（II）-MOF）的纳米粒子修饰。所制备的 Zn（II）-MOF/EDPGE 电极通过电氧化反应用于 SUM 的灵敏电化学检测。Zn（II）-MOF 通过水热合成进行合成并通过各种技术进行表征。PGE 的电化学分层处理导致形成多孔基底，有利于修饰剂的有效固定。设计的传感器受益于增强的表面积和加速的电子转移速率，这可以通过计时库仑图和奈奎斯特图得到证明。在优化条件下，开发的传感器对 0.99-9.52µM SUM 溶液表现出线性响应。所制备的传感器的响应时间短，为 5s，检测限为 0.29µM。通过检查常见于生物样品中的可待因、肾上腺素、对乙酰氨基酚、抗坏血酸和尿酸对 SUM 的干扰效应，评估了 Zn（II）-MOF/EDPGE 对 SUM 的选择性。开发的传感器在分析人血清样品中的 SUM 时，回收率值在 96.6%至 111%的范围内，表现出优异的性能。
