Lund T, Reed R K
Circ Shock. 1986;20(2):105-14.
Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), and cardiac index (CI) were measured in anesthetized rats subjected to thermal injury covering 10 and 40% of the body surface area (BSA). These were compared to corresponding sham controls. No fluid substitution was provided. MAP decreased rapidly from 110 mm Hg preburn and leveled off at 75-80 mm Hg after 60 min postburn in the 40% burn group and at 80-95 mm Hg in the 10% burn group. CVP was not influenced by thermal injury. CI fell from about 270 to 208 and to 173 ml X min-1 X kg-1 during the first 15 min after injury in the 10 and 40% burn groups, respectively. Thereafter, CI continued to fall more slowly in both groups, being lower in the 40% than the 10% burn group for the whole postburn course (P less than .001). HR fell slightly in both burn groups (P greater than .05). Stroke volume index followed the same pattern as CI indicating that the fall in CI was caused by reduction in stroke volume. Total peripheral resistance increased slightly after injury. Previous measurement of hematocrit in thermal injury of the same type and extent suggests a 35% increase in viscosity. Consequently, vascular hindrance was unchanged. Compensatory tachycardia or vasoconstriction could not be demonstrated.
在体表烧伤面积分别为10%和40%的麻醉大鼠中测量心率（HR）、平均动脉压（MAP）、中心静脉压（CVP）和心脏指数（CI）。将这些数据与相应的假手术对照组进行比较。未进行液体替代。在40%烧伤组中，MAP在烧伤前为110 mmHg，烧伤后60分钟迅速降至75 - 80 mmHg并趋于平稳；在10%烧伤组中，MAP在烧伤后60分钟降至80 - 95 mmHg。热损伤对CVP无影响。在10%和40%烧伤组中，CI在损伤后的前15分钟内分别从约270降至208和173 ml·min⁻¹·kg⁻¹。此后，两组CI继续缓慢下降，在整个烧伤后过程中，40%烧伤组的CI低于10%烧伤组（P <.001）。两组烧伤组的HR均略有下降（P >.05）。每搏量指数与CI的变化模式相同，表明CI的下降是由每搏量减少所致。损伤后总外周阻力略有增加。先前对相同类型和程度热损伤的血细胞比容测量表明，粘度增加了35%。因此，血管阻力未变。未发现代偿性心动过速或血管收缩。
