Khan Bilal Ahmed, Syed Imran Ali, Ulhaq Ihsan, Rashid Sohail, Khan Muhammad Yasir, Khalid Abdullah, Shafi Urfa, Aujla Usman Iqbal, Dar Faisal Saud
Pakistan Kidney and Liver Institute & Research Center, DHA Phase VI, Lahore, Pakistan.
ACG Case Rep J. 2023 Oct 3;10(10):e01163. doi: 10.14309/crj.0000000000001163. eCollection 2023 Oct.
Calcifying nested stromal-epithelial tumor is a rare hepatic malignancy with approximately 50 cases reported in the literature. Its clinical presentation is nonspecific, and the diagnosis is mainly based on histology which shows nests of spindle and epithelioid cells along with a desmoplastic myofibroblastic stroma containing variable calcification and ossification. In this report, we present a case of a 24-year-old woman with a history of abdominal pain, distension, and dyspepsia. She had a palpable liver with normal liver function test results. Serum alpha-fetoprotein levels were within normal range, and serologies for hepatitis B and C virus remained negative. Radiological investigations (magnetic resonance imaging and computed tomography) showed a large, right hepatic lobe mass with tumor invasion into the right posterior portal vein, but the 2 modalities could not characterize the lesion. Finally, an ultrasound-guided biopsy of the liver lesion provided the diagnosis of calcifying nested stromal-epithelial tumor. The tumor was resected successfully.
钙化性巢状间质-上皮肿瘤是一种罕见的肝脏恶性肿瘤，文献报道约50例。其临床表现无特异性，诊断主要基于组织学检查，可见梭形细胞和上皮样细胞巢，伴有含不同程度钙化和骨化的促纤维增生性肌成纤维细胞间质。在本报告中，我们介绍了一例24岁女性患者，有腹痛、腹胀和消化不良病史。她可触及肝脏，肝功能检查结果正常。血清甲胎蛋白水平在正常范围内，乙肝和丙肝病毒血清学检查仍为阴性。影像学检查（磁共振成像和计算机断层扫描）显示右肝叶有一个大肿块，肿瘤侵犯右后门静脉，但这两种检查方法均无法明确病变特征。最后，肝脏病变的超声引导下活检确诊为钙化性巢状间质-上皮肿瘤。肿瘤被成功切除。
