Haidari Hamed, Derhartunian Victor, Arba-Mosquera Samuel
Technische Hochschule Aschaffenburg University of Applied Sciences (student), Aschaffenburg, D- 63743, Germany.
SCHWIND eye-tech-solutions, Kleinostheim, D- 63801, Germany.
Biomed Opt Express. 2023 Jul 11;14(8):4080-4096. doi: 10.1364/BOE.495416. eCollection 2023 Aug 1.
A simple and novel method to analyse the centration of a lenticule of tissue extracted from a cornea has been developed, in which the centre of "mass" of the individual differences between post and preoperative maps of several corneal metrics represents the lenticule centration and its spatial distance to a reference point (aimed centration) determines the decentration. Different parameters have been evaluated to weight the centre of "mass". The robustness of the methods has been evaluated using perturbation analysis (adding white-noise to the data) based on realistic uncertainties. A clipped analysis has been performed to prevent large, localised areas of lacking/missing data from affecting the centre of "mass". The method has been tested on a pilot cohort of clinical data showing 30% and 63% of the treatments within 200 µm of decentration for corneal thickness and refractive equivalent power, respectively. Except for anterior elevation with a total standard deviation of 17 µm, all other metrics show excellent precision of ∼5 µm. The method provides a reliable and objective way to determine the centration of a lenticule of tissue extracted from a cornea and it can be applied to any topo- or tomographic derived metric.
已经开发出一种简单且新颖的方法来分析从角膜提取的组织透镜的对中情况，其中几个角膜指标的术后和术前图谱之间个体差异的“质”心代表透镜对中情况，并且其到参考点（目标对中）的空间距离决定偏心情况。已经评估了不同参数以加权“质”心。基于实际不确定性，使用扰动分析（向数据添加白噪声）评估了该方法的稳健性。已经进行了裁剪分析，以防止大面积局部缺失数据影响“质”心。该方法已在一组临床数据的试验队列上进行测试，结果表明，对于角膜厚度和屈光等效度，分别有30%和63%的治疗偏心在200µm以内。除了总标准差为17µm的前表面高度外，所有其他指标的精度均约为5µm，表现出色。该方法为确定从角膜提取的组织透镜的对中情况提供了一种可靠且客观的方式，并且可应用于任何从地形图或断层扫描得出的指标。
