Mino Toshihiro, Moriguchi Yoshikiyo, Tamura Masato, Matsumoto Akiko, Kubota Atsushi, Akiba Masahiro, Hwang Yunchan, Makita Shuichi, Yasuno Yoshiaki, Enaida Hiroshi, Fujimoto James G, Wang Zhenguo
Topcon Advanced Biomedical Imaging Laboratory, Topcon Medical Systems, 111 Bauer Drive, Oakland, NJ 07436, USA.
Research & Development Division, Topcon Corporation, 75-1 Hasunuma-cho, Itabashi-ku, Tokyo 174-8580, Japan.
Biomed Opt Express. 2023 Jul 14;14(8):4112-4125. doi: 10.1364/BOE.491611. eCollection 2023 Aug 1.
A novel scanning protocol, ammonite scan, is proposed for widefield optical coherence tomography angiography (OCTA) and relative retinal blood flow velocity imaging in the human retina using variable interscan time analysis (VISTA). A repeated circle scan using a 400 kHz swept-source was employed to achieve an interscan time of 1.28 ms. The center of the repeated circular scan continuously moved spirally towards the peripheral region, ensuring an extended and adjustable scan range while preserving the short interscan time. Image artifacts due to eye movement were eliminated via extra motion-correction processing using data redundancy. The relative blood flow velocity in superficial and deep plexus layers was calculated from the VISTA image, and their ratio was used to explore the microvascular flow parameter in the healthy human eye.
一种新的扫描协议——菊石扫描被提出，用于宽场光学相干断层扫描血管造影（OCTA）以及使用可变扫描间隔时间分析（VISTA）对人视网膜进行相对视网膜血流速度成像。采用400kHz扫频光源进行重复圆周扫描，以实现1.28 ms的扫描间隔时间。重复圆周扫描的中心持续螺旋式地向周边区域移动，在保持短扫描间隔时间的同时确保扫描范围可扩展且可调。通过使用数据冗余的额外运动校正处理消除了因眼球运动产生的图像伪影。从VISTA图像计算浅表和深部神经丛层的相对血流速度，并利用它们的比值来探究健康人眼的微血管血流参数。
