Liu Gangjun, Yang Jianlong, Wang Jie, Li Yan, Zang Pengxiao, Jia Yali, Huang David
Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
J Biophotonics. 2017 Nov;10(11):1464-1472. doi: 10.1002/jbio.201600325. Epub 2017 May 11.
We developed a high-speed, swept source OCT system for widefield OCT angiography (OCTA) imaging. The system has an extended axial imaging range of 6.6 mm. An electrical lens is used for fast, automatic focusing. The recently developed split-spectrum amplitude and phase-gradient angiography allow high-resolution OCTA imaging with only two B-scan repetitions. An improved post-processing algorithm effectively removed trigger jitter artifacts and reduced noise in the flow signal. We demonstrated high contrast 3 mm×3 mm OCTA image with 400×400 pixels acquired in 3 seconds and high-definition 8 mm×6 mm and 12 mm×6 mm OCTA images with 850×400 pixels obtained in 4 seconds. A widefield 8 mm×11 mm OCTA image is produced by montaging two 8 mm×6 mm scans. An ultra-widefield (with a maximum of 22 mm along both vertical and horizontal directions) capillary-resolution OCTA image is obtained by montaging six 12 mm×6 mm scans.
我们开发了一种用于广角光学相干断层扫描血管造影（OCTA）成像的高速扫频光学相干断层扫描（OCT）系统。该系统具有6.6 mm的扩展轴向成像范围。使用电透镜进行快速自动聚焦。最近开发的分裂谱幅度和相位梯度血管造影技术仅需两次B扫描重复即可实现高分辨率OCTA成像。一种改进的后处理算法有效去除了触发抖动伪影并降低了血流信号中的噪声。我们展示了在3秒内采集的400×400像素、对比度高的3 mm×3 mm OCTA图像，以及在4秒内获得的850×400像素、高清的8 mm×6 mm和12 mm×6 mm OCTA图像。通过拼接两次8 mm×6 mm扫描生成8 mm×11 mm的广角OCTA图像。通过拼接六次12 mm×6 mm扫描获得超广角（垂直和水平方向最大为22 mm）毛细血管分辨率OCTA图像。
