Institute of Physiotherapy, School of Health Professions, Zurich University of Applied Sciences, (ZHAW), Winterthur, Switzerland.
Department of Physical and Occupational Therapy, School of Nursing, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Front Endocrinol (Lausanne). 2023 Sep 20;14:1235030. doi: 10.3389/fendo.2023.1235030. eCollection 2023.
Spinal kinematics/motion are reported to be altered in adolescents and adults with essential obesity, while no information is available in patients with Prader-Willi syndrome so far. The aim of this study was to examine cross-sectionally the characteristics of spinal postures and mobility in 34 patients with PWS, in 35 age- and sex-matched adults with essential obesity, and in 37 normal-weight individuals.
Spinal posture and mobility were assessed using a radiation-free back scan, the Idiag M360 (Idiag, Fehraltorf, Switzerland). Differences in spinal posture and mobility between the three groups were determined using a two-way analysis of variance.
Adults with Prader-Willi syndrome had greater thoracic kyphosis [difference between groups (Δ) = 9.6, 95% CI 3.3 to 15.6, p = 0.001], less lumbar lordosis (Δ = -6.5, 95% CI -12.7 to -0.3, p = 0.03) as well as smaller lumbar and hip mobility than those with normal weight.
Although the characteristics of the spine in patients with Prader-Will syndrome appear to be similar to that found in subjects with essential obesity, Prader-Willi syndrome was found to influence lumbar movements more than thoracic mobility. These results provide relevant information about the characteristics of the spine in adults with Prader-Willi syndrome to be taken into careful consideration in the management of spinal conditions. These findings also highlight the importance of considering the musculoskeletal assessment of spinal postures and approaches targeting spinal and hip flexibility in adults with Prader-Willi syndrome.
据报道，在患有原发性肥胖的青少年和成年人中，脊柱运动学/运动发生改变，而迄今为止，在普拉德-威利综合征（PWS）患者中尚无相关信息。本研究旨在横向比较 34 例 PWS 患者、35 例年龄和性别匹配的原发性肥胖症成年人和 37 例体重正常个体的脊柱姿势和活动度特征。
使用无辐射背扫描仪 Idiag M360（Idiag，瑞士 Fehraltorf）评估脊柱姿势和活动度。使用双因素方差分析确定三组之间脊柱姿势和活动度的差异。
成年 PWS 患者的胸椎后凸增加[组间差异（Δ）= 9.6，95%置信区间（CI）3.3 至 15.6，p = 0.001]，腰椎前凸减少（Δ= -6.5，95% CI -12.7 至 -0.3，p = 0.03），腰椎和髋关节活动度减小。
尽管 PWS 患者的脊柱特征似乎与原发性肥胖症患者相似，但 PWS 更影响腰椎活动度，而非胸椎活动度。这些结果为成年人 PWS 脊柱特征提供了相关信息，在管理脊柱疾病时应予以谨慎考虑。这些发现还强调了在 PWS 成年人中考虑脊柱姿势的肌肉骨骼评估以及针对脊柱和髋关节柔韧性的方法的重要性。
