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Frequency of rare fragile sites among mentally subnormal schoolchildren.

作者信息

Kähkönen M, Leisti J, Thoden C J, Autio S

出版信息

Clin Genet. 1986 Sep;30(3):234-8. doi: 10.1111/j.1399-0004.1986.tb00601.x.

DOI:10.1111/j.1399-0004.1986.tb00601.x
PMID:3780040
Abstract

The frequency of rare fragile sites was studied among 240 children in special schools for subnormal intelligence (IQ 52-85). 1/130 boys studied (0.8%) had the fragile site at Xq27.3 while it was not found in any girl (0/110). In two children an autosomal rare fragile site at 2q11.2 (2/240, 0.8%) was seen. In addition a constitutional chromosome abnormality was found in a further seven children (7/240, 2.9%).

摘要

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引用本文的文献

1
Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites.脆性非凡：染色体脆性位点未解之谜。
Adv Exp Med Biol. 2017;1042:489-526. doi: 10.1007/978-981-10-6955-0_21.
2
FREQUENCY AND DISTRIBUTION OF CHROMOSOME FRAGILE SITES OR LESIONS IN MALES WITH MENTAL RETARDATION: A DESCRIPTIVE STUDY.智力迟钝男性中染色体脆性位点或损伤的频率与分布：一项描述性研究。
J Tenn Acad Sci. 1998 Jul-Oct;73(3-4):87-99.
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Balanced translocations in mental retardation.智力迟钝中的平衡易位
Hum Genet. 2009 Jul;126(1):133-47. doi: 10.1007/s00439-009-0661-6. Epub 2009 Apr 5.
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5
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