McRury J, De Messias I T, Walzer P D, Huitger T, Genta R M
Clin Exp Immunol. 1986 Sep;65(3):631-8.
IgE antibodies directed against Strongyloides stercoralis larval antigens were measured by a newly developed radioallergosorbant test (RAST). One hundred and fifty-two samples of sera from patients with parasitologically proven S. stercoralis infection were tested. One hundred and thirty-six of these (89.5%) were positive for parasite-specific IgE. Of 50 presumably non-infected North American adult control sera, 49 (98%) were negative. All sera from patients with other parasites were negative, except for two sera from subjects with Ascaris lumbricoides, who exhibited low positivity. Of eight sera from non-infected patients with allergies and high IgE levels, one was weakly positive, and the other seven were negative. Considerable individual variability was present in the levels of specific IgE as measured by the RAST in the infected patients. Significant differences were also found among the three major demographic groups which composed our study population, with Asians having higher values than Latin Americans and the latter having higher values than North American patients. We conclude that the majority of patients with strongyloidiasis develop IgE antibodies directed against antigens from filariform larvae, the invasive form of the parasite. While the functional significance of this response remains to be defined, the RAST for IgE may be a useful adjunct in the immunological evaluation of these patients.
通过一种新开发的放射变应原吸附试验（RAST）检测针对粪类圆线虫幼虫抗原的IgE抗体。对152份经寄生虫学证实为粪类圆线虫感染患者的血清样本进行了检测。其中136份（89.5%）寄生虫特异性IgE呈阳性。在50份推测未感染的北美成人对照血清中，49份（98%）为阴性。除了两份来自蛔虫病患者的血清呈低阳性外，所有其他寄生虫患者的血清均为阴性。在8份来自未感染但有过敏且IgE水平高的患者的血清中，1份弱阳性，其他7份阴性。通过RAST检测，感染患者体内特异性IgE水平存在相当大的个体差异。在构成我们研究人群的三个主要人口统计学组之间也发现了显著差异，亚洲人的数值高于拉丁美洲人，而拉丁美洲人的数值高于北美患者。我们得出结论，大多数粪类圆线虫病患者会产生针对丝状幼虫（寄生虫的侵袭性形式）抗原的IgE抗体。虽然这种反应的功能意义尚待确定，但IgE的RAST可能是这些患者免疫评估中的一种有用辅助手段。
