虾青素纳米粒通过减轻氧化应激、调节肠道菌群和保护肠道屏障来改善葡聚糖硫酸钠诱导的结肠炎。
Astaxanthin nanoparticles ameliorate dextran sulfate sodium-induced colitis by alleviating oxidative stress, regulating intestinal flora, and protecting the intestinal barrier.
机构信息
Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, Jiangsu, P. R. China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Key Laboratory of Animal Protein Food Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, Zhejiang, PR China.
出版信息
Food Funct. 2023 Oct 30;14(21):9567-9579. doi: 10.1039/d3fo03331g.
This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and to investigate its effect and alleviation mechanism on colitis in mice. We demonstrated that MFGM-GA-astaxanthin could improve the bioaccessibility of astaxanthin and cope with oxidative stress more effectively in a Caco-2 cell model. studies demonstrated that MFGM-GA-astaxanthin alleviated colitis symptoms and repaired intestinal barrier function by increasing the expression of mucin 2, occludin, and zonula occludens-1. This was attributed to the alleviating effect of MFGM-GA-astaxanthin on oxidative stress. Moreover, MFGM-GA-astaxanthin restored the abnormalities of flora caused by dextran sulfate sodium, including , , , and . This study provides a basis for the therapeutic effect of astaxanthin nanoparticles on colon diseases.
本研究旨在开发一种新型虾青素纳米粒子，使用阿拉伯胶（GA）和富含乳脂肪球膜（MFGM-WPI）的乳清蛋白粉作为载体，并研究其对结肠炎小鼠的作用和缓解机制。我们证明 MFGM-GA-虾青素可以提高虾青素的生物利用度，并在 Caco-2 细胞模型中更有效地应对氧化应激。研究表明，MFGM-GA-虾青素通过增加粘蛋白 2、闭合蛋白和紧密连接蛋白-1 的表达来缓解结肠炎症状和修复肠道屏障功能。这归因于 MFGM-GA-虾青素对氧化应激的缓解作用。此外，MFGM-GA-虾青素恢复了葡聚糖硫酸钠引起的菌群异常，包括 、 、 和 。本研究为虾青素纳米粒子治疗结肠疾病的疗效提供了依据。
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