School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China.
School of Physics and Electrical Engineering, Linyi University, Linyi 276000, China.
ACS Sens. 2023 Oct 27;8(10):3952-3963. doi: 10.1021/acssensors.3c01594. Epub 2023 Oct 6.
Developing a respiratory analysis disease diagnosis platform for the HS biomarker has great significance for the real-time detection of various diseases. However, achieving highly sensitive and rapid detection of HS gas at the parts per billion level at low temperatures is one of the most critical challenges for developing portable exhaled gas sensors. Herein, CuO-multiwalled carbon nanotube (MWCNT) heterostructures with excellent gas sensitivity to HS at room temperature and a lower temperature were successfully synthesized by a facile two-dimensional (2D) electrodeposition in situ assembly method. The combination of CuO and MWCNTs via the principle of optimal conductance growth not only reduced the initial resistance of the material but also provided an ideal interfacial barrier structure. Compared to the response of the pure CuO sensor, that of the CuO-MWCNT sensor to 1 ppm of HS increased nearly 800 times at room temperature, and the response time decreased by more than 500 s. In addition to the excellent sensitivity with detection limits as low as 1 ppb, the CuO-MWCNT sensor was extremely selective with low-temperature adaptability. The sensor had a response value of 80.6 to 0.1 ppm of HS at -10 °C, which is difficult to achieve with sensors based on oxygen adsorption/desorption mechanisms. The sensor was used for the detection of real oral exhaled breath, confirming its feasibility as a real-time disease monitoring sensor. The CuO-MWCNT heterostructures maximized the advantages of the individual components and laid the experimental foundation for future applications of highly sensitive portable breath analysis platforms for monitoring HS.
开发针对 HS 生物标志物的呼吸分析疾病诊断平台对于实时检测各种疾病具有重要意义。然而，在低温下实现对 HS 气体在十亿分之一水平的高灵敏度和快速检测是开发便携式呼气气体传感器的最关键挑战之一。在此，通过简便的二维（2D）电沉积原位组装方法成功合成了对室温下和低温下 HS 具有优异气体敏感性的 CuO-多壁碳纳米管（MWCNT）异质结构。CuO 和 MWCNTs 通过最佳导电机理结合不仅降低了材料的初始电阻，而且提供了理想的界面势垒结构。与纯 CuO 传感器的响应相比，CuO-MWCNT 传感器对 1 ppm 的 HS 的响应在室温下增加了近 800 倍，响应时间减少了 500 多秒。除了具有检测限低至 1 ppb 的优异灵敏度外，CuO-MWCNT 传感器还具有极低的低温适应性和极高的选择性。该传感器在-10°C 时对 0.1 ppm 的 HS 的响应值为 80.6，这是基于氧吸附/解吸机制的传感器难以实现的。该传感器用于检测真实的口腔呼出呼吸，证实了其作为实时疾病监测传感器的可行性。CuO-MWCNT 异质结构最大限度地发挥了各组件的优势，为未来开发用于监测 HS 的高灵敏度便携式呼吸分析平台奠定了实验基础。
