CuO/CoO nanoarrays for rapid quantitative analysis of hydrogen sulfide in blood.

2D heterostructure nanoarrays have emerged as a promising sensing material for rapid disease detection applications. In this study, a bio-HS sensor based on CuO/CoO nanoarrays was proposed, the controllable preparation of the nanoarrays being achieved by exploring the experimental parameters of the 2D electrodeposition assembly process. The nanoarrays were designed as a multi-barrier system with strict periodicity and long-range order. Based on the interfacial conductance modulation and vulcanization reaction of CuO and CoO, the sensor exhibited superior sensitivity, selectivity, and stability to HS in human blood. In addition, the sensor exhibited a reasonable response to 0.1 μmol L NaS solution, indicating that it had a low detection limit for practical applications. Moreover, first-principles calculations were performed to study changes in the heterointerface during the sensing process and the mechanism of rapid response of the sensor. This work demonstrated the reliability of CuO/CoO nanoarrays applied in portable sensors for the rapid detection of bio-HS.